Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 10/20 | 0.43 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.35 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.35 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.33 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 2/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 2/20 | 0.32 |
| ▸ | MMP14 | P50281 | 1/20 | 0.32 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4120221 | 1.00 | CNR2 (0.43) | CNR2CNR1PSMB8PSMB9PSMB5 | |
| SCHEMBL1176346 | 0.94 | CNR2 (0.48) | CNR2CNR1PSMB8PSMB9PSMB5 | |
| SCHEMBL1176344 | 0.94 | CNR2 (0.48) | CNR2CNR1PSMB8PSMB9PSMB5 | |
| SCHEMBL1175191 | 0.90 | CNR2 (0.42) | CNR2CNR1MMP1RAB9ACTSK | |
| SCHEMBL1175308 | 0.84 | CNR2 (0.41) | CNR2CNR1PSMB8PSMB9PSMB5 | |
| SCHEMBL1175311 | 0.84 | CNR2 (0.41) | CNR2CNR1PSMB8PSMB9PSMB5 | |
| SCHEMBL1174255 | 0.83 | CNR2 (0.44) | CNR2CNR1MMP1RAB9AMMP9 | |
| SCHEMBL1174253 | 0.83 | CNR2 (0.44) | CNR2CNR1MMP1RAB9AMMP9 | |
| SCHEMBL12883456 | 0.83 | CNR2 (0.44) | CNR2CNR1MMP1RAB9AMMP9 | |
| SCHEMBL1174498 | 0.82 | CNR2 (0.60) | CNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8431565-B2 | Substituted imidazoheterocycles | CARA THERAPEUTICS, INC. (US) | 2013-04-30 | — | — | US | disclosed |
| US-20090149450-A1 | SUBSTITUTED IMIDAZOHETEROCYCLES | CARA THERAPEUTICS, INC. (US) | 2009-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149450-A1 | SUBSTITUTED IMIDAZOHETEROCYCLES | CNR1, CNR2, TRPV1 | CNR2 2/4885CNR1 1/4885PSMB8 2966/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.