Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 7/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | CCR1 | P32246 | 2/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | VHL | P40337 | 2/20 | 0.30 |
| ▸ | ELOC | Q15369 | 1/20 | 0.30 |
| ▸ | ELOB | Q15370 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4121049 | 1.00 | CNR2 (0.52) | CNR2PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL4110959 | 0.94 | CNR2 (0.51) | CNR2PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL4110956 | 0.94 | CNR2 (0.51) | CNR2PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL4128310 | 0.94 | CNR2 (0.55) | CNR2CCR1VHLELOCELOB | |
| SCHEMBL4128344 | 0.93 | CNR2 (0.56) | CNR2PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL4128350 | 0.93 | CNR2 (0.56) | CNR2PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL4113778 | 0.91 | CNR2 (0.54) | CNR2CCR1 | |
| SCHEMBL4113782 | 0.91 | CNR2 (0.54) | CNR2CCR1 | |
| SCHEMBL4113846 | 0.90 | CNR2 (0.53) | CNR2PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL4113850 | 0.90 | CNR2 (0.53) | CNR2PDE4BPDE4DPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8431565-B2 | Substituted imidazoheterocycles | CARA THERAPEUTICS, INC. (US) | 2013-04-30 | — | — | US | disclosed |
| US-20090149450-A1 | SUBSTITUTED IMIDAZOHETEROCYCLES | CARA THERAPEUTICS, INC. (US) | 2009-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149450-A1 | SUBSTITUTED IMIDAZOHETEROCYCLES | CNR1, CNR2, TRPV1 | CNR2 2/4885PDE4B 3700/4885PDE4D 3987/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.