Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 20/20 | 0.51 |
| ▸ | PDE2A | O00408 | 1/20 | 0.49 |
| ▸ | PDE5A | O76074 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.49 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4122628 | 0.81 | PDE10A (0.73) | PDE10APDE2APDE5APDE4APDE4D | |
| SCHEMBL4124572 | 0.78 | PDE10A (0.62) | PDE10APDE2APDE5APDE4APDE4D | |
| SCHEMBL4124867 | 0.78 | PDE10A (0.62) | PDE10APDE2APDE5APDE4APDE4D | |
| SCHEMBL4110025 | 0.74 | PDE10A (0.57) | PDE10APDE2APDE5APDE4APDE4D | |
| SCHEMBL4122699 | 0.72 | PDE10A (0.79) | PDE10APDE2APDE5APDE4APDE4D | |
| SCHEMBL4106503 | 0.70 | PDE10A (0.49) | PDE10APDE2APDE5APDE4APDE4D | |
| SCHEMBL4120681 | 0.67 | PDE10A (0.52) | PDE10APDE2APDE5APDE4APDE4D | |
| SCHEMBL3997814 | 0.66 | PDE10A (1.00) | PDE10APDE2APDE5APDE4APDE4D | |
| SCHEMBL7909727 | 0.65 | PDE10A (0.70) | PDE10APDE2APDE5APDE4APDE4D | |
| SCHEMBL3995422 | 0.63 | PDE10A (1.00) | PDE10APDE2APDE5APDE4APDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070583-A1 | PYRIDO[3,2-E]PYRAZINES, PROCESS FOR PREPARING THE SAME, AND THEIR USE AS INHIBITORS OF PHOSPHODIESTERASE 10 | WYETH (US) | 2009-06-04 | — | — | WO | disclosed |