Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4112204 | 1.00 | KMT2A (0.47) | KMT2AMEN1ACHEHTTNPC1 | |
| SCHEMBL13775372 | 0.85 | KMT2A (0.49) | KMT2AMEN1ACHEHTTALDH1A1 | |
| SCHEMBL7750057 | 0.83 | KMT2A (0.56) | KMT2AMEN1ACHEALDH1A1MAPT | |
| SCHEMBL2825482 | 0.81 | KMT2A (0.56) | KMT2AMEN1ACHEALDH1A1LMNA | |
| SCHEMBL4534838 | 0.80 | KMT2A (0.53) | KMT2AMEN1ACHENPC1ALDH1A1 | |
| SCHEMBL22042521 | 0.80 | MEN1 (0.46) | KMT2AMEN1ACHENPC1ALDH1A1 | |
| SCHEMBL22042598 | 0.79 | KMT2A (0.48) | KMT2AMEN1ACHENPC1ALDH1A1 | |
| SCHEMBL31092647 | 0.79 | KMT2A (0.48) | KMT2AMEN1ACHENPC1ALDH1A1 | |
| SCHEMBL4117456 | 0.77 | MEN1 (0.70) | KMT2AMEN1ACHEHTTNPC1 | |
| SCHEMBL4117452 | 0.77 | MEN1 (0.70) | KMT2AMEN1ACHEHTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090181942-A1 | TRICYCLIC COMPOUNDS | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2009-07-16 | — | — | US | disclosed |
| EP-1939205-A1 | TRICYCLIC COMPOUND | Daiichi Sankyo Company, Limited (JP) | 2008-07-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181942-A1 | TRICYCLIC COMPOUNDS | FDFT1, COASY, HMGCR | KMT2A 1467/4885MEN1 2041/4885ACHE 434/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.