Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.79 |
| ▸ | BACE2 | Q9Y5Z0 | 19/20 | 0.79 |
| ▸ | CTSD | P07339 | 18/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4120125 | 0.88 | BACE1 (0.73) | BACE1BACE2CTSD | |
| SCHEMBL4736850 | 0.88 | BACE1 (0.80) | BACE1BACE2CTSD | |
| SCHEMBL4783931 | 0.87 | BACE1 (0.82) | BACE1BACE2CTSD | |
| SCHEMBL4527892 | 0.85 | BACE1 (0.80) | BACE1BACE2CTSD | |
| SCHEMBL4115835 | 0.85 | BACE1 (0.63) | BACE1BACE2CTSD | |
| SCHEMBL4784497 | 0.85 | BACE1 (0.79) | BACE1BACE2CTSD | |
| SCHEMBL3540525 | 0.84 | BACE1 (1.00) | BACE1BACE2CTSD | |
| SCHEMBL3541409 | 0.84 | BACE1 (1.00) | BACE1BACE2CTSD | |
| SCHEMBL7921520 | 0.84 | BACE1 (1.00) | BACE1BACE2CTSD | |
| SCHEMBL7915445 | 0.84 | BACE1 (1.00) | BACE1BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090233943-A9 | NEW COMPOUNDS 835 | ASTEX THERAPEUTICS LIMITED (GB) | 2009-09-17 | — | — | US | claimed |
| US-20080287460-A1 | NEW COMPOUNDS 835 | ASTEX THERAPEUTICS LIMITED (GB) | 2008-11-20 | — | — | US | claimed |
| US-20090233943-A9 | NEW COMPOUNDS 835 | ASTEX THERAPEUTICS LIMITED (GB) | 2009-09-17 | — | — | US | disclosed |
| US-20090233943-A9 | NEW COMPOUNDS 835 | ASTEX THERAPEUTICS LIMITED (GB) | 2009-09-17 | — | — | US | disclosed |
| US-20080287460-A1 | NEW COMPOUNDS 835 | ASTEX THERAPEUTICS LIMITED (GB) | 2008-11-20 | — | — | US | disclosed |
| US-20080287460-A1 | NEW COMPOUNDS 835 | ASTEX THERAPEUTICS LIMITED (GB) | 2008-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287460-A1 | NEW COMPOUNDS 835 | GRIK5, MAPT, PSEN1 | BACE1 6/4885BACE2 25/4885CTSD 1954/4885 |
| US-20090233943-A9 | NEW COMPOUNDS 835 | GRIK5, MAPT, PSEN1 | BACE1 6/4885BACE2 25/4885CTSD 1954/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.