Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.38 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4116747 | 0.88 | LPAR1 (0.45) | LPAR1LMNASMN1; SMN2RECQLALDH1A1 | |
| SCHEMBL4124330 | 0.86 | LPAR1 (0.40) | LPAR1ALDH1A1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL4125981 | 0.86 | KMT2A (0.42) | LPAR1LMNASMN1; SMN2RECQLALDH1A1 | |
| SCHEMBL4129998 | 0.84 | LPAR1 (0.48) | LPAR1LMNASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL4124875 | 0.83 | LPAR1 (0.45) | LPAR1LMNASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL4122916 | 0.82 | LPAR1 (0.56) | LPAR1LMNASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL4123090 | 0.81 | LPAR1 (0.50) | LPAR1LMNASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL4125868 | 0.81 | LPAR1 (0.50) | LPAR1LMNASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL4118297 | 0.81 | LPAR1 (0.49) | LPAR1LMNAALDH1A1KMT2APOLB | |
| SCHEMBL4134040 | 0.79 | LPAR1 (0.49) | LPAR1LMNASMN1; SMN2RECQLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090181942-A1 | TRICYCLIC COMPOUNDS | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2009-07-16 | — | — | US | disclosed |
| EP-1939205-A1 | TRICYCLIC COMPOUND | Daiichi Sankyo Company, Limited (JP) | 2008-07-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181942-A1 | TRICYCLIC COMPOUNDS | FDFT1, COASY, HMGCR | LPAR1 345/4885LMNA 1109/4885SMN1; SMN2 4445/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.