Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 10/20 | 0.55 |
| ▸ | HPRT1 | P00492 | 9/20 | 0.54 |
| ▸ | POLG | P54098 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | POLA1 | P09884 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11307134 | 1.00 | PNP (0.55) | PNPHPRT1POLGPOLBPOLA1 | |
| SCHEMBL4125073 | 1.00 | PNP (0.55) | PNPHPRT1POLGPOLBPOLA1 | |
| SCHEMBL13742486 | 1.00 | PNP (0.55) | PNPHPRT1POLGPOLBPOLA1 | |
| SCHEMBL4125066 | 1.00 | PNP (0.55) | PNPHPRT1POLGPOLBPOLA1 | |
| SCHEMBL4118715 | 0.98 | PNP (0.56) | PNPHPRT1POLGPOLBPOLA1 | |
| SCHEMBL4118717 | 0.98 | PNP (0.56) | PNPHPRT1POLGPOLBPOLA1 | |
| SCHEMBL4118713 | 0.98 | PNP (0.56) | PNPHPRT1POLGPOLBPOLA1 | |
| SCHEMBL4117111 | 0.95 | PNP (0.57) | PNPHPRT1POLGPOLBPOLA1 | |
| SCHEMBL4117109 | 0.95 | PNP (0.57) | PNPHPRT1POLGPOLBPOLA1 | |
| SCHEMBL4117119 | 0.95 | PNP (0.57) | PNPHPRT1POLGPOLBPOLA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8222257-B2 | Phosphono-pent-2-en-1-yl nucleosides and analogs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-07-17 | — | — | US | disclosed |
| US-20090215726-A1 | Phosphono-Pent-2-en-1-yl Nucleosides and Analogs | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-08-27 | — | — | US | disclosed |
| EP-1866319-A1 | PHOSPHONO-PENT-2-EN-1-YL NUCLEOSIDES AND ANALOGS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006137953-A1 | PHOSPHONO-PENT-2-EN-1-YL NUCLEOSIDES AND ANALOGS | THE REGENTS OF THE UNIVERISITY OF CALIFORNIA (US) | 2006-12-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215726-A1 | Phosphono-Pent-2-en-1-yl Nucleosides and Analogs | PNP, TYMP, ENPP1 | PNP 1/4885HPRT1 215/4885POLG 161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.