Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | SLC8B1 | Q6J4K2 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.41 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.36 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4121445 | 1.00 | MAPT (0.45) | MAPTCYP2C9TSHRCYP2C19TP53 | |
| SCHEMBL4121440 | 1.00 | MAPT (0.45) | MAPTCYP2C9TSHRCYP2C19TP53 | |
| SCHEMBL4121444 | 1.00 | MAPT (0.45) | MAPTCYP2C9TSHRCYP2C19TP53 | |
| SCHEMBL14146204 | 0.91 | GLA (0.42) | MAPTCYP2C9TSHRCYP2C19TP53 | |
| SCHEMBL4110833 | 0.91 | MAPT (0.55) | MAPTCYP2C9TSHRCYP2C19TP53 | |
| SCHEMBL4110842 | 0.91 | MAPT (0.55) | MAPTCYP2C9TSHRCYP2C19TP53 | |
| SCHEMBL4110835 | 0.91 | MAPT (0.55) | MAPTCYP2C9TSHRCYP2C19TP53 | |
| SCHEMBL4123154 | 0.88 | EGFR (0.43) | MAPTCYP2C9TSHRCYP2C19TP53 | |
| SCHEMBL4123148 | 0.88 | EGFR (0.43) | MAPTCYP2C9TSHRCYP2C19TP53 | |
| SCHEMBL4123158 | 0.88 | EGFR (0.43) | MAPTCYP2C9TSHRCYP2C19TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090181942-A1 | TRICYCLIC COMPOUNDS | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2009-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181942-A1 | TRICYCLIC COMPOUNDS | FDFT1, COASY, HMGCR | MAPT 4428/4885CYP2C9 1280/4885TSHR 1672/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.