Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 13/20 | 0.49 |
| ▸ | DPP7 | Q9UHL4 | 7/20 | 0.49 |
| ▸ | DPP8 | Q6V1X1 | 5/20 | 0.49 |
| ▸ | DPP9 | Q86TI2 | 5/20 | 0.49 |
| ▸ | FAP | Q12884 | 1/20 | 0.49 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8351360 | 1.00 | DPP4 (0.49) | DPP4DPP7DPP8DPP9FAP | |
| SCHEMBL14655433 | 1.00 | DPP4 (0.49) | DPP4DPP7DPP8DPP9FAP | |
| Hydrochloric Acid SCHEMBL2377064 | 0.98 | DPP4 (0.47) | DPP4DPP7DPP8DPP9FAP | |
| Hydrochloric Acid SCHEMBL2377058 | 0.98 | DPP4 (0.47) | DPP4DPP7DPP8DPP9FAP | |
| SCHEMBL6316252 | 0.98 | DPP4 (0.47) | DPP4DPP7DPP8DPP9FAP | |
| SCHEMBL14655634 | 0.98 | DPP4 (0.47) | DPP4DPP7DPP8DPP9FAP | |
| SCHEMBL342909 | 0.96 | DPP4 (0.49) | DPP4DPP7DPP8DPP9FAP | |
| SCHEMBL342908 | 0.96 | DPP4 (0.49) | DPP4DPP7DPP8DPP9FAP | |
| SCHEMBL23421170 | 0.83 | DPP4 (0.45) | DPP4DPP7DPP8DPP9FAP | |
| SCHEMBL10296210 | 0.83 | DPP4 (0.46) | DPP4DPP7DPP8DPP9FAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8431565-B2 | Substituted imidazoheterocycles | CARA THERAPEUTICS, INC. (US) | 2013-04-30 | — | — | US | claimed |
| US-20090149450-A1 | SUBSTITUTED IMIDAZOHETEROCYCLES | CARA THERAPEUTICS, INC. (US) | 2009-06-11 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149450-A1 | SUBSTITUTED IMIDAZOHETEROCYCLES | CNR1, CNR2, TRPV1 | DPP4 4359/4885DPP7 3990/4885DPP8 3805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.