Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 14/20 | 0.47 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.47 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.46 |
| ▸ | PTPRC | P08575 | 2/20 | 0.44 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4125811 | 0.84 | PTPN1 (0.55) | PTPN1PTPN2PTPRC | |
| SCHEMBL4125670 | 0.81 | PTPN1 (0.58) | PTPN1PTPN2PTPRC | |
| SCHEMBL4126876 | 0.80 | PTPN1 (0.59) | PTPN1PTPN2PTPRC | |
| SCHEMBL4126991 | 0.80 | PTPN1 (0.63) | PTPN1PTPN2PTPRC | |
| SCHEMBL4126654 | 0.80 | PTPN1 (0.59) | PTPN1PTPN2PTPRC | |
| SCHEMBL4118995 | 0.79 | PTPN1 (0.47) | PTPN1PTPN2PTPRC | |
| SCHEMBL4123945 | 0.79 | PTPN1 (0.64) | PTPN1PTPN2PTPRC | |
| SCHEMBL4122921 | 0.79 | PTPN1 (0.45) | PTPN1PTPN2PTPRC | |
| SCHEMBL4120104 | 0.79 | PTPN1 (0.60) | PTPN1PTPN2PTPRCKDM4EHPGD | |
| SCHEMBL4127708 | 0.78 | PTPN1 (0.49) | PTPN1PTPN2PTPRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090048286-A1 | Inhibitors of Protein Tyrosine Phosphatase 1B | WYETH (US) | 2009-02-19 | — | — | US | disclosed |
| US-20050203081-A1 | Inhibitors of protein tyrosine phosphatase 1B | WYETH | 2005-09-15 | — | — | US | disclosed |
| WO-2005081960-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B | WYETH (US) | 2005-09-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203081-A1 | Inhibitors of protein tyrosine phosphatase 1B | PTPRS, PTPRO, PTPRM | PTPN1 11/4885PTPN2 23/4885TNFRSF1A 1048/4885 |
| US-20090048286-A1 | Inhibitors of Protein Tyrosine Phosphatase 1B | PTPRS, PTPRO, PTPRM | PTPN1 11/4885PTPN2 23/4885TNFRSF1A 1048/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.