Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 11/20 | 0.70 |
| ▸ | CNR1 | P21554 | 7/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4126660 | 1.00 | CNR2 (0.70) | CNR2CNR1PIK3CAADAM17TP53 | |
| SCHEMBL4115717 | 0.94 | CNR2 (0.71) | CNR2CNR1PIK3CAADAM17TP53 | |
| SCHEMBL1175740 | 0.92 | CNR2 (0.71) | CNR2CNR1ADAM17TP53THRB | |
| SCHEMBL1175737 | 0.92 | CNR2 (0.71) | CNR2CNR1ADAM17TP53THRB | |
| SCHEMBL4115521 | 0.91 | CNR2 (0.69) | CNR2CNR1ADAM17TP53THRB | |
| SCHEMBL4115517 | 0.91 | CNR2 (0.69) | CNR2CNR1ADAM17TP53THRB | |
| SCHEMBL1174744 | 0.90 | CNR2 (0.71) | CNR2CNR1PIK3CAADAM17 | |
| SCHEMBL1174751 | 0.90 | CNR2 (0.71) | CNR2CNR1PIK3CAADAM17 | |
| SCHEMBL4115721 | 0.90 | CNR2 (0.71) | CNR2CNR1ADAM17 | |
| SCHEMBL4115713 | 0.90 | CNR2 (0.71) | CNR2CNR1ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8431565-B2 | Substituted imidazoheterocycles | CARA THERAPEUTICS, INC. (US) | 2013-04-30 | — | — | US | disclosed |
| US-8431565-B2 | Substituted imidazoheterocycles | CARA THERAPEUTICS, INC. (US) | 2013-04-30 | — | — | US | disclosed |
| US-8431565-B2 | Substituted imidazoheterocycles | CARA THERAPEUTICS, INC. (US) | 2013-04-30 | — | — | US | disclosed |
| US-20090149450-A1 | SUBSTITUTED IMIDAZOHETEROCYCLES | CARA THERAPEUTICS, INC. (US) | 2009-06-11 | — | — | US | disclosed |
| US-20090149450-A1 | SUBSTITUTED IMIDAZOHETEROCYCLES | CARA THERAPEUTICS, INC. (US) | 2009-06-11 | — | — | US | disclosed |
| US-20090149450-A1 | SUBSTITUTED IMIDAZOHETEROCYCLES | CARA THERAPEUTICS, INC. (US) | 2009-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149450-A1 | SUBSTITUTED IMIDAZOHETEROCYCLES | CNR1, CNR2, TRPV1 | CNR2 2/4885CNR1 1/4885PIK3CA 1365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.