Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 10/20 | 0.62 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.38 |
| ▸ | FAP | Q12884 | 2/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21661368 | 0.84 | DPP4 (0.46) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL12732485 | 0.82 | DPP4 (0.58) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL19845903 | 0.79 | DPP4 (0.41) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL19000043 | 0.79 | DPP4 (0.41) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL19000008 | 0.79 | DPP4 (0.41) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL19334938 | 0.79 | DPP4 (0.66) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL11907188 | 0.76 | DPP4 (0.52) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL30853669 | 0.76 | DPP4 (0.52) | DPP4ALDH1A1MAPTPTGS1CA2 | |
| SCHEMBL30811203 | 0.76 | DPP4 (0.51) | DPP4TSHRALDH1A1MAPTPTGS1 | |
| SCHEMBL31520397 | 0.76 | DPP4 (0.51) | DPP4DPP8DPP9FAPDPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8431565-B2 | Substituted imidazoheterocycles | CARA THERAPEUTICS, INC. (US) | 2013-04-30 | — | — | US | claimed |
| US-20090149450-A1 | SUBSTITUTED IMIDAZOHETEROCYCLES | CARA THERAPEUTICS, INC. (US) | 2009-06-11 | — | — | US | claimed |
| US-20170333461-A1 | PEPTIDOMIMETIC INHIBITORS OF POST-PROLINE CLEAVING ENZYMES | BACH BIOSCIENCES, LLC | 2017-11-23 | — | — | US | disclosed |
| US-9757400-B2 | Peptidomimetic inhibitors of post-proline cleaving enzymes | TRUSTEES OF TUFTS COLLEGE (US) | 2017-09-12 | — | — | US | disclosed |
| US-20160158260-A1 | Peptidomimetic Inhibitors of Post-Proline Cleaving Enzymes | BACH BIOSCIENCES, LLC | 2016-06-09 | — | — | US | disclosed |
| US-20110082108-A1 | Peptidomimetic Inhibitors of Post-Proline Cleaving Enzymes | TRUSTEES OF TUFTS COLLEGE (US) | 2011-04-07 | — | — | US | disclosed |
| US-7727964-B2 | Peptidomimetic inhibitors of post-proline cleaving enzymes | TRUSTEES OF TUFTS COLLEGE (US) | 2010-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149450-A1 | SUBSTITUTED IMIDAZOHETEROCYCLES | CNR1, CNR2, TRPV1 | DPP4 4359/4885DPP8 3805/4885DPP9 4313/4885 |
| US-20110082108-A1 | Peptidomimetic Inhibitors of Post-Proline Cleaving Enzymes | PREP, PEPD, DNPEP | DPP4 4/4885DPP8 11/4885DPP9 8/4885 |
| US-20170333461-A1 | PEPTIDOMIMETIC INHIBITORS OF POST-PROLINE CLEAVING ENZYMES | PREP, PEPD, DNPEP | DPP4 5/4885DPP8 11/4885DPP9 9/4885 |
| US-20160158260-A1 | Peptidomimetic Inhibitors of Post-Proline Cleaving Enzymes | PREP, PEPD, DNPEP | DPP4 5/4885DPP8 11/4885DPP9 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.