Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 13/20 | 0.53 |
| ▸ | PTPN2 | P17706 | 10/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3919036 | 0.83 | PTPN1 (0.56) | PTPN1PTPN2 | |
| SCHEMBL3209574 | 0.83 | PTPN1 (0.56) | PTPN1PTPN2 | |
| SCHEMBL2935888 | 0.81 | PTPN1 (0.59) | PTPN1PTPN2 | |
| SCHEMBL2935544 | 0.81 | PTPN1 (0.55) | PTPN1PTPN2 | |
| SCHEMBL4785433 | 0.80 | PTPN1 (0.51) | PTPN1PTPN2 | |
| SCHEMBL12971498 | 0.80 | PTPN1 (0.60) | PTPN1PTPN2 | |
| SCHEMBL3225865 | 0.80 | PTPN1 (0.53) | PTPN1PTPN2 | |
| SCHEMBL12971497 | 0.79 | PTPN1 (0.55) | PTPN1PTPN2 | |
| SCHEMBL12056190 | 0.79 | PTPN1 (0.47) | PTPN1PTPN2 | |
| SCHEMBL2937663 | 0.79 | PTPN1 (0.52) | PTPN1PTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038267-A2 | THIADIAZOLIDINONE INHIBITORS OF PTPASE | Novartis AG (CH) | 2009-03-25 | — | — | EP | disclosed |
| WO-2007115058-A2 | THIADIAZOLIDINONE INHIBITORS OF PTPASE | NOVARTIS AG (CH) | 2007-10-11 | — | — | WO | disclosed |