Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 7/20 | 0.62 |
| ▸ | CDK7 | P50613 | 2/20 | 0.62 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.62 |
| ▸ | CCND1 | P24385 | 1/20 | 0.62 |
| ▸ | CCNC | P24863 | 1/20 | 0.62 |
| ▸ | CDK9 | P50750 | 1/20 | 0.62 |
| ▸ | CCNH | P51946 | 1/20 | 0.62 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.62 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.62 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.61 |
| ▸ | AXL | P30530 | 1/20 | 0.56 |
| ▸ | FEN1 | P39748 | 3/20 | 0.53 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.53 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.53 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.52 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29479416 | 0.88 | CDK8 (0.61) | CDK8CDK7CCNT1CCND1CCNC | |
| SCHEMBL945016 | 0.82 | CDK8 (0.60) | CDK8CDK7CCNT1CCND1CCNC | |
| SCHEMBL3795698 | 0.80 | CDK8 (0.49) | CDK8CDK7CCNT1CCND1CCNC | |
| SCHEMBL31064990 | 0.79 | CDK8 (0.64) | CDK8CDK7CCNT1CCND1CCNC | |
| SCHEMBL12127568 | 0.79 | CDK8 (0.64) | CDK8CDK7CCNT1CCND1CCNC | |
| SCHEMBL858203 | 0.79 | CDK8 (0.64) | CDK8CDK7CCNT1CCND1CCNC | |
| SCHEMBL31095069 | 0.77 | CDK8 (0.64) | CDK8CDK7CCNT1CCND1CCNC | |
| SCHEMBL31127659 | 0.77 | PARP1 (0.54) | MAP4K4PDGFRBPDGFRACSNK1G2CLK4 | |
| SCHEMBL995473 | 0.77 | PARP1 (0.54) | MAP4K4PDGFRBPDGFRACSNK1G2CLK4 | |
| SCHEMBL299518 | 0.77 | CDK8 (1.00) | CDK8CDK7CCNT1CCND1CCNC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2064213-A1 | HETEROARYL DERIVATIVES AS PROTEIN KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2009-06-03 | — | — | EP | claimed |
| WO-2008028617-A1 | HETEROARYL DERIVATIVES AS PROTEIN KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-13 | — | — | WO | claimed |
| US-20090318428-A1 | HETEROARYL DERIVATIVES AS PROTEIN KINASE INHIBITORS | HOFFMANN-LA ROCHE, INC. | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318428-A1 | HETEROARYL DERIVATIVES AS PROTEIN KINASE INHIBITORS | MAP3K5, MAP3K1, PRKACA | CDK8 314/4885CDK7 282/4885CCNT1 1405/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.