Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 12/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 11/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.34 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4115374 | 0.81 | MAPK1 (0.48) | GAAMAPK1 | |
| SCHEMBL19207222 | 0.75 | HDAC4 (0.48) | HDAC4 | |
| SCHEMBL4941675 | 0.74 | KDM4E (0.60) | KDM4EGAAMAPTHDAC1HDAC3 | |
| SCHEMBL4941681 | 0.74 | KDM4E (0.60) | KDM4EGAAMAPTHDAC1HDAC3 | |
| SCHEMBL16989782 | 0.71 | KDM4E (0.49) | KDM4EGAAMAPTHDAC1HDAC3 | |
| SCHEMBL16989781 | 0.71 | KDM4E (0.49) | KDM4EGAAMAPTHDAC1HDAC3 | |
| SCHEMBL720368 | 0.71 | MAPT (0.81) | KDM4EGAAMAPTHDAC1HDAC3 | |
| SCHEMBL30657522 | 0.71 | MAPT (0.81) | KDM4EGAAMAPTHDAC1HDAC3 | |
| SCHEMBL20302269 | 0.70 | MAPT (0.55) | KDM4EGAAMAPTHDAC1HDAC3 | |
| SCHEMBL20334339 | 0.70 | MAPT (0.55) | KDM4EGAAMAPTHDAC1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778231-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2009-06-03 | — | — | EP | disclosed |
| EP-1778231-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006020415-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-02-23 | — | — | WO | disclosed |