Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 12/20 | 0.74 |
| ▸ | RPS6KA5 | O75582 | 10/20 | 0.55 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.55 |
| ▸ | PRKACA | P17612 | 2/20 | 0.55 |
| ▸ | GSK3B | P49841 | 2/20 | 0.55 |
| ▸ | CDK2 | P24941 | 2/20 | 0.55 |
| ▸ | RPS6KA1 | Q15418 | 2/20 | 0.55 |
| ▸ | CDC7 | O00311 | 1/20 | 0.55 |
| ▸ | PLK4 | O00444 | 1/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.55 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.55 |
| ▸ | PRKCG | P05129 | 1/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
| ▸ | PIM1 | P11309 | 1/20 | 0.55 |
| ▸ | MARK3 | P27448 | 1/20 | 0.55 |
| ▸ | AKT1 | P31749 | 1/20 | 0.55 |
| ▸ | AKT2 | P31751 | 1/20 | 0.55 |
| ▸ | FLT4 | P35916 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4117733 | 0.91 | ROCK1 (0.74) | ROCK1RPS6KA5RPS6KB1PRKACAGSK3B | |
| SCHEMBL5007596 | 0.89 | ROCK1 (0.70) | ROCK1RPS6KA5RPS6KB1PRKACAGSK3B | |
| SCHEMBL4007830 | 0.87 | ROCK1 (0.77) | ROCK1RPS6KA5RPS6KB1PRKACAGSK3B | |
| SCHEMBL4001678 | 0.87 | ROCK1 (0.80) | ROCK1RPS6KA5RPS6KB1PRKACAGSK3B | |
| SCHEMBL4719379 | 0.86 | ROCK1 (1.00) | ROCK1RPS6KA5RPS6KB1PRKACAGSK3B | |
| SCHEMBL4008323 | 0.85 | ROCK1 (0.87) | ROCK1RPS6KA5RPS6KB1PRKACAGSK3B | |
| SCHEMBL4000963 | 0.84 | ROCK1 (0.89) | ROCK1RPS6KA5RPS6KB1PRKACAGSK3B | |
| SCHEMBL4000983 | 0.84 | ROCK1 (0.89) | ROCK1RPS6KA5RPS6KB1PRKACAGSK3B | |
| SCHEMBL3997341 | 0.84 | ROCK1 (0.76) | ROCK1RPS6KA5RPS6KB1PRKACAGSK3B | |
| SCHEMBL4008585 | 0.84 | ROCK1 (1.00) | ROCK1RPS6KA5RPS6KB1PRKACAGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675552-A4 | PREPERATION OF 1,6-DISUBSTITUTED AZABENZIMIDAZOLES AS KINASE INHIBITORS | GLAXO GROUP LTD (GB) | 2009-06-03 | — | — | EP | disclosed |
| EP-1675552-A2 | PREPERATION OF 1,6-DISUBSTITUTED AZABENZIMIDAZOLES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005037197-A2 | PREPERATION OF 1,6-DISUBSTITUTED AZABENZIMIDAZOLES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2005-04-28 | — | — | WO | disclosed |