SCHEMBL4129635

SCHEMBL4129635

CCOC(=O)[C@@H]1C[C@@H]1c1ccccc1

nearest known ligand 0.63

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.62
PKM P14618 1/20 0.62
TSHR P16473 1/20 0.55
MAPK1 P28482 1/20 0.55
SMN1; SMN2 Q16637 1/20 0.55
TDP1 Q9NUW8 1/20 0.55
MEN1 O00255 3/20 0.53
KMT2A Q03164 3/20 0.53
HDAC4 P56524 1/20 0.51
ALDH1A1 P00352 3/20 0.51
HTT P42858 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
CYP1A2 P05177 1/20 0.50
CYP2D6 P10635 1/20 0.50
CYP2C19 P33261 1/20 0.50
HRH3 Q9Y5N1 1/20 0.49
SIGMAR1 Q99720 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12706756 1.00 MAPT (0.62) MAPTPKMTSHRMAPK1SMN1; SMN2
SCHEMBL12908208 1.00 MAPT (0.62) MAPTPKMTSHRMAPK1SMN1; SMN2
SCHEMBL12706755 1.00 MAPT (0.62) MAPTPKMTSHRMAPK1SMN1; SMN2
SCHEMBL12908203 1.00 MAPT (0.62) MAPTPKMTSHRMAPK1SMN1; SMN2
SCHEMBL928888 1.00 MAPT (0.62) MAPTPKMTSHRMAPK1SMN1; SMN2
SCHEMBL14270533 1.00 MAPT (0.62) MAPTPKMTSHRMAPK1SMN1; SMN2
SCHEMBL4135351 1.00 MAPT (0.62) MAPTPKMTSHRMAPK1SMN1; SMN2
SCHEMBL31451008 0.95 MAPT (0.58) MAPTPKMTSHRMAPK1SMN1; SMN2
SCHEMBL11695165 0.95 MAPT (0.58) MAPTPKMTSHRMAPK1SMN1; SMN2
SCHEMBL15797827 0.94 MAPT (0.56) MAPTPKMTSHRMAPK1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3495349-B1 (HETERO)ARYL CYCLOPROPYLAMINE COMPOUNDS AS LSD1 INHIBITORS ORYZON GENOMICS SA (ES) 2023-06-28 EP disclosed
EP-4074695-A1 (HETERO)ARYL CYCLOPROPYLAMINE COMPOUNDS AS LSD1 INHIBITORS Oryzon Genomics, S.A. (ES) 2022-10-19 EP disclosed
US-11008596-B2 Cytochrome P450 BM3 enzyme variants for preparation of cyclopropanes CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2021-05-18 US disclosed
US-20190211367-A1 VIVO AND IN VITRO OLEFIN CYCLOPROPANATION CATALYZED BY HEME ENZYMES CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2019-07-11 US disclosed
US-10208322-B2 In vivo and in vitro olefin cyclopropanation catalyzed by heme enzymes CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2019-02-19 US disclosed
EP-2881384-B1 PARTIALLY SATURATED NITROGEN-CONTAINING HETEROCYCLIC COMPOUND TAISHO PHARMACEUTICAL CO LTD (JP) 2018-05-30 EP disclosed
US-20180079709-A1 (HETERO)ARYL CYCLOPROPYLAMINE COMPOUNDS AS LSD1 INHIBITORS ORYZON GENOMICS SA (ES) 2018-03-22 US disclosed
US-20180079709-A1 (HETERO)ARYL CYCLOPROPYLAMINE COMPOUNDS AS LSD1 INHIBITORS ORYZON GENOMICS SA (ES) 2018-03-22 US disclosed
US-20170247725-A1 IN VIVO AND IN VITRO OLEFIN CYCLOPROPANATION CATALYZED BY HEME ENZYMES CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2017-08-31 US disclosed
US-20170247725-A1 IN VIVO AND IN VITRO OLEFIN CYCLOPROPANATION CATALYZED BY HEME ENZYMES CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2017-08-31 US disclosed
US-5602267-A Organometallic catalysts for epoxidizing prochiral olefins and a new class of amid-salicylidene ligands HOECHST CELANESE (US) 1997-02-11 US disclosed
US-5508458-A USEFUL IN EPOXIDATION OF OLEFINS HOECHST CELANESE CORPORATION (US) 1996-04-16 US disclosed
US-5491266-A REACTING CHIRAL COMPOUND IN PRESENCE OF OPTICALLY ACTIVE METAL-LIGAND COMPLEX UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) 1996-02-13 US disclosed
EP-0600020-B1 ASYMMETRIC SYNTHESES UNION CARBIDE CHEM PLASTIC (US) 1996-01-31 EP disclosed
EP-0673381-A1 HOMOGENEOUS BIMETALLIC HYDROFORMYLATION CATALYSTS AND PROCESSES UTILIZING THESE CATALYSTS FOR CONDUCTING HYDROFORMYLATION REACTIONS THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) 1995-09-27 EP disclosed
US-5360938-A Metal ligand complex phosphite hydrogenation catalysts UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) 1994-11-01 US disclosed
WO-1994020510-A1 HOMOGENEOUS BIMETALLIC HYDROFORMYLATION CATALYSTS AND PROCESSES UTILIZING THESE CATALYSTS FOR CONDUCTING HYDROFORMYLATION REACTIONS BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) 1994-09-15 WO disclosed
EP-0600020-A1 ASYMMETRIC SYNTHESES. UNION CARBIDE CHEM PLASTIC (US) 1994-06-08 EP disclosed
WO-1993003839-A1 ASYMMETRIC SYNTHESES UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) 1993-03-04 WO disclosed
US-4016204-A ISOMERIZING ETHYL-2-PHENYL-CYCLOPROPANE CARBOXYLATE NELSON RESEARCH & DEVELOPMENT COMPANY (US) 1977-04-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180079709-A1 (HETERO)ARYL CYCLOPROPYLAMINE COMPOUNDS AS LSD1 INHIBITORS KDM1B, KDM1A, KDM2A MAPT 383/4885PKM 805/4885TSHR 4205/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.