Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 3/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.34 |
| ▸ | FLT3 | P36888 | 5/20 | 0.34 |
| ▸ | TPH1 | P17752 | 1/20 | 0.33 |
| ▸ | TPH2 | Q8IWU9 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3933348 | 0.95 | ITK (0.45) | ITKSYKFGFR1FGFR2FGFR3 | |
| SCHEMBL3927781 | 0.92 | ITK (0.43) | ITKSYKFGFR1FGFR2FGFR3 | |
| Trifluoroacetic Acid SCHEMBL4130010 | 0.92 | SYK (0.43) | ITKSYKFGFR1FGFR2FGFR3 | |
| Trifluoroacetic Acid SCHEMBL4138498 | 0.90 | SYK (0.41) | ITKSYKFGFR1FGFR2FGFR3 | |
| SCHEMBL3928874 | 0.87 | SYK (0.46) | ITKSYKFGFR1FGFR2FGFR3 | |
| SCHEMBL4129225 | 0.84 | SYK (0.44) | ITKSYKFGFR1FGFR2FGFR3 | |
| SCHEMBL4130131 | 0.84 | FGFR1 (0.43) | ITKFGFR1FGFR2FGFR3KDR | |
| Trifluoroacetic Acid SCHEMBL4142647 | 0.81 | FGFR1 (0.40) | ITKSYKFGFR1FGFR2FGFR3 | |
| SCHEMBL4134571 | 0.81 | FGFR1 (0.41) | ITKFGFR1FGFR2FGFR3KDR | |
| Trifluoroacetic Acid SCHEMBL4129766 | 0.79 | SYK (0.46) | ITKSYKKDRKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9126969-B2 | Pyrazolylbenzimidazole derivatives, compositions containing them and use thereof | AVENTIS PHARMA S.A. (FR) | 2015-09-08 | — | — | US | disclosed |
| US-20090197866-A1 | PYRAZOLYLBENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM AND USE THEREOF | AVENTIS PHARMA S.A. (FR) | 2009-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090197866-A1 | PYRAZOLYLBENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM AND USE THEREOF | RB1, CCNI, CDK2 | ITK 1817/4885SYK 392/4885FGFR1 2171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.