Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Rocuronium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.99 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.99 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.58 |
| ▸ | SLC47A2 | Q86VL8 | 1/20 | 0.58 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | RAD52 | P43351 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rocuronium SCHEMBL1036090 | 1.00 | KCNH2 (0.99) | KCNH2AGTR1SLC22A2SLC47A2SLC47A1 | |
| Rocuronium SCHEMBL1036092 | 1.00 | KCNH2 (0.99) | KCNH2AGTR1SLC22A2SLC47A2SLC47A1 | |
| Rocuronium SCHEMBL6067603 | 1.00 | KCNH2 (0.99) | KCNH2AGTR1SLC22A2SLC47A2SLC47A1 | |
| Rocuronium SCHEMBL3835255 | 1.00 | KCNH2 (0.99) | KCNH2AGTR1SLC22A2SLC47A2SLC47A1 | |
| Rocuronium SCHEMBL3986752 | 1.00 | KCNH2 (0.99) | KCNH2AGTR1SLC22A2SLC47A2SLC47A1 | |
| Rocuronium SCHEMBL3986751 | 1.00 | KCNH2 (0.99) | KCNH2AGTR1SLC22A2SLC47A2SLC47A1 | |
| Rocuronium SCHEMBL6067600 | 1.00 | KCNH2 (0.99) | KCNH2AGTR1SLC22A2SLC47A2SLC47A1 | |
| Bromide SCHEMBL10589679 | 0.99 | KCNH2 (0.97) | KCNH2AGTR1SLC22A2SLC47A2SLC47A1 | |
| Bromide SCHEMBL10589682 | 0.99 | KCNH2 (0.97) | KCNH2AGTR1SLC22A2SLC47A2SLC47A1 | |
| Rocuronium SCHEMBL3823993 | 0.99 | KCNH2 (1.00) | KCNH2AGTR1SLC22A2SLC47A2SLC47A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2249 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076560-B1 | SURFACE MODIFYING COATING FOR MEDICAL DEVICES | HOSPIRA INC (US) | 2026-04-01 | — | — | EP | claimed |
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| EP-4687914-A1 | A ROOM-TEMPERATURE STABLE, UNBUFFERED FORMULATION OF ROCURONIUM BROMIDE INJECTION FOR INTRAVENOUS ADMINISTRATION AND A METHOD THEREOF | Maiva Pharma Private Limited (IN) | 2026-02-11 | — | — | EP | claimed |
| US-20250339621-A1 | ROCURONIUM IN PREFILLED SYRINGES | BRAUN MELSUNGEN AG (DE) | 2025-11-06 | — | — | US | claimed |
| EP-4618945-A1 | COMPOSITION COMPRISING ROCURONIUM | B. Braun Melsungen AG (DE) | 2025-09-24 | — | — | EP | claimed |
| US-20250242092-A1 | SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS | SIO2 MEDICAL PRODUCTS INC (US) | 2025-07-31 | — | — | US | claimed |
| CN-120142194-A | Optical fiber sensor for detecting drug concentration and drug concentration detection system | 西安交通大学医学院第一附属医院 | 2025-06-13 | — | — | CN | claimed |
| CN-118319854-B | Prefilled sodium gluconate and sodium chloride injection | 天津睿创康泰生物技术有限公司 | 2025-05-16 | — | — | CN | claimed |
| CN-119909011-A | Preparation method of rocuronium bromide injection | 华中药业股份有限公司 | 2025-05-02 | — | — | CN | claimed |
| CN-119816504-A | Imidazolium salt macrocyclic compound, and preparation method and application thereof | 复旦大学 | 2025-04-11 | — | — | CN | claimed |
| US-6949527-B2 | 6-Mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block | AKZO NOBEL N.V. (NL) | 2005-09-27 | — | — | US | claimed |
| WO-2005068487-A2 | PROCESSES FOR THE PREPARATION OF ROCURONIUM BROMIDE AND INTERMEDIATES THEREOF | CHEMAGIS LTD. (IL) | 2005-07-28 | — | — | WO | claimed |
| US-20050159398-A1 | Processes for the preparation of rocuronium bromide and intermediates thereof | WAVELENGTH ENTERPRISES LTD (IL) | 2005-07-21 | — | — | US | claimed |
| US-20050153932-A1 | Controlled muscle relaxation | N.V. ORGANON (NL) | 2005-07-14 | — | — | US | claimed |
| US-20050137141-A1 | Prodrug composition | HILFINGER JOHN (US) | 2005-06-23 | — | — | US | claimed |
| CN-1188428-C | 6-mercapto-cyclodextrin derivs.: resersal agent for drug-induced neuromuscular block | AKZO NOBEL NV (NL) | 2005-02-09 | — | — | CN | claimed |
| US-20040029833-A1 | 6-Mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block | MERCK SHARP & DOHME B.V. (NL) | 2004-02-12 | — | — | US | claimed |
| CN-1370073-A | Use of chemical chelators as reversal agents for drug-induced neuromuscular block | AKZO NOBEL NV (NL) | 2002-09-18 | — | — | CN | claimed |
| WO-2000044334-A2 | NOVEL INJECTABLE MUSCLE RELAXANT FORMULATIONS | PATEL DINESH SHANTILAL (IN) | 2000-08-03 | — | — | WO | claimed |
| US-5767112-A | ACIDIC MIXTURE FOR INJECTION COMPRISING NEUROMUSCULAR BLOCKING AGENT AND ZWITTERION HAVING ISOELECTRIC POINT GREATER THAN 7; SHELF LIFE, ANESTHETIC | POLI INDUSTRIA CHIMICA, S.P.A. (IT) | 1998-06-16 | — | — | US | claimed |