Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 12/20 | 0.73 |
| ▸ | MAPK9 | P45984 | 11/20 | 0.73 |
| ▸ | MAPK10 | P53779 | 9/20 | 0.73 |
| ▸ | CDK2 | P24941 | 8/20 | 0.73 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.73 |
| ▸ | CDK1 | P06493 | 1/20 | 0.66 |
| ▸ | CDK4 | P11802 | 1/20 | 0.66 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.66 |
| ▸ | CCND1 | P24385 | 1/20 | 0.66 |
| ▸ | JUN | P05412 | 1/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 8/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 7/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL473468 | 0.87 | MAPK8 (0.78) | MAPK8MAPK9MAPK10CDK2CCNE1 | |
| SCHEMBL4004010 | 0.87 | MAPK8 (0.78) | MAPK8MAPK9MAPK10CDK2CCNE1 | |
| SCHEMBL473564 | 0.86 | MAPK8 (0.68) | MAPK8MAPK9MAPK10CDK2CCNE1 | |
| SCHEMBL473566 | 0.85 | MAPK8 (0.85) | MAPK8MAPK9MAPK10CDK2CCNE1 | |
| SCHEMBL473393 | 0.84 | MAPK8 (1.00) | MAPK8MAPK9MAPK10CDK2CCNE1 | |
| SCHEMBL473392 | 0.84 | MAPK8 (1.00) | MAPK8MAPK9MAPK10CDK2CCNE1 | |
| SCHEMBL473557 | 0.84 | MAPK8 (1.00) | MAPK8MAPK9MAPK10CDK2CCNE1 | |
| SCHEMBL473522 | 0.84 | MAPK8 (0.68) | MAPK8MAPK9MAPK10CDK2CCNE1 | |
| SCHEMBL473558 | 0.84 | MAPK8 (1.00) | MAPK8MAPK9MAPK10CDK2CCNE1 | |
| SCHEMBL473426 | 0.84 | MAPK8 (1.00) | MAPK8MAPK9MAPK10CDK2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066319-A1 | BENZOTRIAZOLE KINASE MODULATORS | F. Hoffmann-Roche AG (CH) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008028860-A1 | BENZOTRIAZOLE KINASE MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-13 | — | — | WO | disclosed |