Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.34 |
| ▸ | FDFT1 | P37268 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4133613 | 1.00 | KDM4E (0.36) | KDM4EGAALMNAPLA2G1BMAPT | |
| SCHEMBL4130138 | 0.92 | GAA (0.40) | KDM4EGAALMNAPLA2G1BMAPT | |
| SCHEMBL4130145 | 0.92 | GAA (0.40) | KDM4EGAALMNAPLA2G1BMAPT | |
| SCHEMBL13775457 | 0.92 | NR1H4 (0.36) | KDM4EGAA | |
| SCHEMBL4112306 | 0.92 | FDFT1 (0.41) | KDM4EGAAMAPTFDFT1 | |
| SCHEMBL4112300 | 0.92 | FDFT1 (0.41) | KDM4EGAAMAPTFDFT1 | |
| SCHEMBL4110619 | 0.88 | FDFT1 (0.39) | KDM4EMAPTFDFT1CA2CA5A | |
| SCHEMBL4110617 | 0.88 | FDFT1 (0.39) | KDM4EMAPTFDFT1CA2CA5A | |
| SCHEMBL4110419 | 0.87 | FDFT1 (0.34) | FDFT1 | |
| SCHEMBL4110425 | 0.87 | FDFT1 (0.34) | FDFT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090181942-A1 | TRICYCLIC COMPOUNDS | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2009-07-16 | — | — | US | disclosed |
| EP-1939205-A1 | TRICYCLIC COMPOUND | Daiichi Sankyo Company, Limited (JP) | 2008-07-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181942-A1 | TRICYCLIC COMPOUNDS | FDFT1, COASY, HMGCR | KDM4E 2123/4885GAA 922/4885LMNA 1109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.