Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 15/20 | 0.97 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.55 |
| ▸ | HTR6 | P50406 | 1/20 | 0.51 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.47 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3997414 | 1.00 | HRH4 (0.97) | HRH4HRH3HTR6PRKD1PRKD2 | |
| SCHEMBL3997187 | 0.99 | HRH4 (1.00) | HRH4HRH3HTR6 | |
| SCHEMBL3993315 | 0.86 | HRH4 (0.84) | HRH4 | |
| SCHEMBL4122731 | 0.83 | HRH4 (0.72) | HRH4HRH3 | |
| SCHEMBL3994713 | 0.82 | HRH4 (0.70) | HRH4HTR6PRKD1PRKD2 | |
| SCHEMBL3996342 | 0.79 | HRH4 (0.97) | HRH4HRH3HTR6 | |
| SCHEMBL23173867 | 0.77 | HRH4 (0.97) | HRH4HRH3HTR6PRKD1PRKD2 | |
| SCHEMBL9884847 | 0.77 | HRH4 (0.59) | HRH4 | |
| SCHEMBL603922 | 0.76 | HRH4 (0.97) | HRH4HTR6PRKD1PRKD2 | |
| SCHEMBL9884848 | 0.76 | HRH4 (0.58) | HRH4HRH3HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066645-A2 | 2 AMINO-PYRIMIDINE DERIVATIVES AS H4 RECEPTOR ANTAGONISTS, PROCESSES FOR PREPARING THEM AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS | UCB Pharma S.A. (BE) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008031556-A2 | 2 AMINO-PYRIMIDINE DERIVATIVES AS H4 RECEPTOR ANTAGONISTS, PROCESSES FOR PREPARING THEM AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS | UCB PHARMA, S.A. (BE) | 2008-03-20 | — | — | WO | disclosed |