Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.55 |
| ▸ | ACHE | P22303 | 11/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | NAAA | Q02083 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3663445 | 0.84 | EPHX1 (0.61) | EPHX1ACHETSHRHPGDNAAA | |
| SCHEMBL7534754 | 0.84 | EPHX1 (0.61) | EPHX1ACHETSHRHPGDNAAA | |
| SCHEMBL8997419 | 0.84 | EPHX1 (0.61) | EPHX1ACHETSHRHPGDNAAA | |
| SCHEMBL7534806 | 0.84 | EPHX1 (0.61) | EPHX1ACHETSHRHPGDNAAA | |
| SCHEMBL5924841 | 0.79 | HPGD (0.57) | EPHX1ACHETSHRHPGD | |
| SCHEMBL8662880 | 0.79 | EPHX1 (0.60) | EPHX1ACHENAAA | |
| SCHEMBL5138773 | 0.79 | — | — | |
| SCHEMBL14321821 | 0.77 | HPGD (0.50) | EPHX1ACHETSHRHPGD | |
| SCHEMBL14321822 | 0.77 | HPGD (0.50) | EPHX1ACHETSHRHPGD | |
| SCHEMBL10699583 | 0.76 | EPHX1 (0.56) | EPHX1ACHETSHRNAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066662-B1 | SERINE HYDROLASE INHIBITORS | KYORIN SEIYAKU KK (JP) | 2012-12-05 | — | — | EP | claimed |
| CN-102379872-A | Compounds, compositions and methods of inhibiting a-synuclein toxicity | WHITEHEAD BIOMEDICAL INST | 2012-03-21 | — | — | CN | claimed |
| CN-102351880-A | Cyanoaminoquinolones and tetrazoloaminoquinolones as GSK-3 inhibitors | KYORIN SEIYAKU KK | 2012-02-15 | — | — | CN | claimed |
| CN-101855228-A | Cyanoaminoquinolones and tetrazoloaminoquinolones as GSK-3 inhibitors | ACTIVX BIOSCIENCES INC | 2010-10-06 | — | — | CN | claimed |
| CN-101611008-A | C3A receptor modulators and methods of use thereof | ENCYSIVE PHARMACEUTICALS INC (US) | 2009-12-23 | — | — | CN | claimed |
| CN-101535304-A | Serine hydrolase inhibitors | ACTIVX BIOSCIENCES INC (US) | 2009-09-16 | — | — | CN | claimed |
| EP-2066662-A2 | SERINE HYDROLASE INHIBITORS | Activx Biosciences, Inc. (US) | 2009-06-10 | — | — | EP | claimed |
| CN-101410384-A | Compounds and methods for modulating protein trafficking | FOLDRX PHARMACEUTICALS INC (US) | 2009-04-15 | — | — | CN | claimed |
| CN-101374842-A | Azepinoindole derivatives as pharmaceutical agents | EXELIXIS INC (US) | 2009-02-25 | — | — | CN | claimed |
| WO-2008036379-A2 | SERINE HYDROLASE INHIBITORS | ACTIVX BIOSCIENCES, INC. (US) | 2008-03-27 | — | — | WO | claimed |
| CN-101094833-A | Tetrapeptide analogs | IDUN PHARMACEUTICALS INC (US) | 2007-12-26 | — | — | CN | claimed |
| CN-101060839-A | Compounds, compositions and methods for inhibiting alpha-synuclein toxicity | WHITEHEAD BIOMEDICAL INST (US) | 2007-10-24 | — | — | CN | claimed |
| CN-1984883-A | Substituted n-aryl benzamides and related compounds for treatment of amyloid diseases and synucleinopathies | PROTEOTECH INC (US) | 2007-06-20 | — | — | CN | claimed |
| CN-1373751-A | 'Alpha'-amino-'beta'-sulfonyl hydroxamic acid compounds | SEARLE & CO (US) | 2002-10-09 | — | — | CN | claimed |
| EP-0566157-A1 | Neutral metalloendopeptidase inhibitors in the treatment of hypertension | SCHERING CORPORATION (US) | 1993-10-20 | — | — | EP | claimed |
| US-4749688-A | Use of neutral metalloendopeptidase inhibitors in the treatment of hypertension | SCHERING CORPORATION (US) | 1988-06-07 | — | — | US | claimed |
| EP-0254032-A2 | Neutral metalloendopeptidase inhibitors in the treatment of hypertension | SCHERING CORPORATION (US) | 1988-01-27 | — | — | EP | claimed |
| CN-102351880-B | Cyanoaminoquinolones and tetrazoloaminoquinolones as GSK-3 inhibitors | KYORIN SEIYAKU KK | 2014-11-12 | — | — | CN | disclosed |
| US-4749688-A | Use of neutral metalloendopeptidase inhibitors in the treatment of hypertension | SCHERING CORPORATION (US) | 1988-06-07 | — | — | US | disclosed |
| EP-0254032-A2 | Neutral metalloendopeptidase inhibitors in the treatment of hypertension | SCHERING CORPORATION (US) | 1988-01-27 | — | — | EP | disclosed |