Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4169500 | 0.94 | KDM4E (0.49) | KDM4ESMN1; SMN2CYP1A2HTR2AHTR2C | |
| Trifluoroacetic Acid SCHEMBL4125523 | 0.90 | KDM4E (0.61) | KDM4ESMN1; SMN2CYP1A2HTR2AHTR2C | |
| Trifluoroacetic Acid SCHEMBL4125521 | 0.90 | KDM4E (0.61) | KDM4ESMN1; SMN2CYP1A2HTR2AHTR2C | |
| Trifluoroacetic Acid SCHEMBL4142666 | 0.86 | KDM4E (0.56) | KDM4ESMN1; SMN2CYP1A2HTR2AHTR2C | |
| Trifluoroacetic Acid SCHEMBL4142668 | 0.86 | KDM4E (0.56) | KDM4ESMN1; SMN2CYP1A2HTR2AHTR2C | |
| SCHEMBL4131578 | 0.84 | KDM4E (0.46) | KDM4ESMN1; SMN2CYP1A2HTR2AHTR2C | |
| SCHEMBL4131576 | 0.84 | KDM4E (0.46) | KDM4ESMN1; SMN2CYP1A2HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL4129204 | 0.83 | KDM4E (0.64) | KDM4ESMN1; SMN2CYP1A2HTR2AHTR2C | |
| SCHEMBL4135830 | 0.81 | KDM4E (0.42) | KDM4ESMN1; SMN2CYP1A2HTR2AHTR2C | |
| SCHEMBL4135833 | 0.81 | KDM4E (0.42) | KDM4ESMN1; SMN2CYP1A2HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090111760-A1 | MACROLONE COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2009-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090111760-A1 | MACROLONE COMPOUNDS | CYP51A1, MRPL21, MYD88 | KDM4E 3897/4885SMN1; SMN2 2560/4885CYP1A2 146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.