Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 6/20 | 1.00 |
| ▸ | AURKA | O14965 | 5/20 | 0.51 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.49 |
| ▸ | MGAM | O43451 | 1/20 | 0.49 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.49 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.49 |
| ▸ | PLA2G12A | Q9BZM1 | 1/20 | 0.49 |
| ▸ | DAO | P14920 | 1/20 | 0.47 |
| ▸ | AKT2 | P31751 | 1/20 | 0.45 |
| ▸ | CLK2 | P49760 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9119078 | 0.84 | HSP90AA1 (0.72) | HSP90AA1AURKADAOKDM4EMAPT | |
| SCHEMBL5431254 | 0.79 | HSP90AA1 (0.71) | HSP90AA1AURKADAOAKT2CLK2 | |
| SCHEMBL5434927 | 0.79 | HSP90AA1 (1.00) | HSP90AA1DAOAKT2CLK2DYRK1A | |
| SCHEMBL5437772 | 0.78 | HSP90AA1 (0.69) | HSP90AA1AURKADAOAKT2CLK2 | |
| SCHEMBL5440403 | 0.78 | HSP90AA1 (0.69) | HSP90AA1AURKADAOAKT2CLK2 | |
| SCHEMBL5440578 | 0.78 | HSP90AA1 (0.74) | HSP90AA1AURKAAKT2CLK2DYRK1A | |
| SCHEMBL9559146 | 0.77 | HSP90AA1 (0.62) | HSP90AA1AURKADAOKDM4EMAPT | |
| SCHEMBL9119941 | 0.77 | HSP90AA1 (0.75) | HSP90AA1AURKADAOAKT2CLK2 | |
| SCHEMBL5439923 | 0.76 | HSP90AA1 (0.66) | HSP90AA1AURKADAOAKT2CLK2 | |
| SCHEMBL5447991 | 0.76 | HSP90AA1 (0.66) | HSP90AA1AURKADAOAKT2CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090069341-A1 | INHIBITORS OF HSP90 | CHENE PATRICK | 2009-03-12 | — | — | US | disclosed |
| US-20070105862-A1 | Heat-shock protein binders | ABBOTT LABORATORIES | 2007-05-10 | — | — | US | disclosed |
| EP-1776110-A1 | INHIBITORS OF HSP90 | Novartis AG (CH) | 2007-04-25 | — | — | EP | disclosed |
| WO-2006010594-A1 | INHIBITORS OF HSP90 | NOVARTIS AG (CH) | 2006-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069341-A1 | INHIBITORS OF HSP90 | HSP90AB1, HSP90B1, HSP90AA1 | HSP90AA1 3/4885AURKA 977/4885PLA2G10 4514/4885 |
| US-20070105862-A1 | Heat-shock protein binders | HSP90AB1, HSP90AB2P, HSP90B1 | HSP90AA1 5/4885AURKA 3202/4885PLA2G10 4115/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.