Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.72 |
| ▸ | MEN1 | O00255 | 9/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.72 |
| ▸ | POLB | P06746 | 6/20 | 0.72 |
| ▸ | THRB | P10828 | 4/20 | 0.72 |
| ▸ | RECQL | P46063 | 4/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.72 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.72 |
| ▸ | USP2 | O75604 | 3/20 | 0.72 |
| ▸ | BLM | P54132 | 3/20 | 0.72 |
| ▸ | HPGD | P15428 | 2/20 | 0.72 |
| ▸ | APEX1 | P27695 | 2/20 | 0.72 |
| ▸ | PTPN22 | Q9Y2R2 | 2/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.72 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.72 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.72 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13852445 | 1.00 | MAPT (0.72) | MAPTMEN1KMT2AALDH1A1POLB | |
| SCHEMBL2778876 | 0.88 | MAPT (0.71) | MAPTMEN1KMT2AALDH1A1POLB | |
| SCHEMBL19425711 | 0.88 | MAPT (0.71) | MAPTMEN1KMT2AALDH1A1POLB | |
| SCHEMBL5970105 | 0.87 | BCL2 (0.80) | MAPTMEN1KMT2AALDH1A1POLB | |
| SCHEMBL5970104 | 0.87 | BCL2 (0.80) | MAPTMEN1KMT2AALDH1A1POLB | |
| SCHEMBL13852446 | 0.85 | DUSP3 (0.64) | MAPTMEN1KMT2AALDH1A1POLB | |
| SCHEMBL14680229 | 0.84 | MAPT (1.00) | MAPTMEN1KMT2AALDH1A1POLB | |
| SCHEMBL13852582 | 0.81 | MAPT (1.00) | MAPTMEN1KMT2AALDH1A1POLB | |
| SCHEMBL2789751 | 0.81 | MAPT (1.00) | MAPTMEN1KMT2AALDH1A1POLB | |
| SCHEMBL13657864 | 0.81 | MAPT (1.00) | MAPTMEN1KMT2AALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090124675-A1 | INHIBITORS OF ANTI-APOPTOTIC PROTEINS | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2009-05-14 | — | — | US | claimed |
| US-20090124675-A1 | INHIBITORS OF ANTI-APOPTOTIC PROTEINS | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2009-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124675-A1 | INHIBITORS OF ANTI-APOPTOTIC PROTEINS | BAX, BCL2, BAK1 | MAPT 3907/4885MEN1 4293/4885KMT2A 4499/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.