Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.33 |
| ▸ | MERTK | Q12866 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.30 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL415905 | 1.00 | FLT3 (0.39) | FLT3JAK2CCNA2CDK2CCNA1 | |
| SCHEMBL463810 | 0.79 | EGFR (0.36) | FLT3AXLTYRO3MERTK | |
| SCHEMBL415863 | 0.77 | CDK2 (0.49) | FLT3JAK2CCNA2CDK2CCNA1 | |
| SCHEMBL463769 | 0.77 | FLT3 (0.40) | FLT3JAK2CCNA2CDK2CCNA1 | |
| SCHEMBL415811 | 0.77 | FLT3 (0.40) | FLT3JAK2CCNA2CDK2CCNA1 | |
| SCHEMBL414868 | 0.77 | FLT3 (0.40) | FLT3JAK2CCNA2CDK2CCNA1 | |
| SCHEMBL10258190 | 0.77 | FLT3 (0.40) | FLT3JAK2CCNA2CDK2CCNA1 | |
| SCHEMBL463800 | 0.77 | JAK2 (0.33) | FLT3JAK2CCNA2CDK2CCNA1 | |
| SCHEMBL413775 | 0.76 | JAK2 (0.40) | FLT3JAK2CCNA2CDK2CCNA1 | |
| SCHEMBL10258292 | 0.76 | JAK2 (0.42) | FLT3JAK2CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065395-A1 | 2,4 (4,6) PYRIMIDINE DERIVATIVES | FREYNE EDDY JEAN EDGARD (BE) | 2012-03-15 | — | — | US | disclosed |
| US-20120065395-A1 | 2,4 (4,6) PYRIMIDINE DERIVATIVES | FREYNE EDDY JEAN EDGARD (BE) | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065395-A1 | 2,4 (4,6) PYRIMIDINE DERIVATIVES | NR0B1, NR1H3, NCOA3 | FLT3 2149/4885JAK2 2835/4885CCNA2 1274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.