⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8592365 | 0.92 | TTR (0.32) | — | |
| SCHEMBL9130067 | 0.92 | TTR (0.32) | — | |
| SCHEMBL8519521 | 0.88 | — | — | |
| SCHEMBL9751991 | 0.73 | — | — | |
| SCHEMBL6356274 | 0.73 | — | — | |
| SCHEMBL14341603 | 0.73 | NPC1 (0.30) | — | |
| SCHEMBL414440 | 0.71 | — | — | |
| SCHEMBL526486 | 0.71 | — | — | |
| SCHEMBL11496071 | 0.71 | — | — | |
| SCHEMBL4835952 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9603829-B2 | HSP90 inhibitors with modified toxicity | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2017-03-28 | — | — | US | claimed |
| EP-2190291-B1 | HSP90 INHIBITORS WITH MODIFIED TOXICITY | UNIV COLORADO REGENTS (US) | 2015-10-14 | — | — | EP | claimed |
| US-20140315845-A1 | HSP90 INHIBITORS WITH MODIFIED TOXICITY | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE | 2014-10-23 | — | — | US | claimed |
| US-8551964-B2 | Hsp90 inhibitors with modified toxicity | THE REGENTS OF THE UNIVERSITY OF COLORADO (US) | 2013-10-08 | — | — | US | claimed |
| WO-2013074695-A1 | HSP90 INHIBITORS WITH MODIFIED TOXICITY | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2013-05-23 | — | — | WO | claimed |
| US-20120022011-A1 | HSP90 INHIBITORS WITH MODIFIED TOXICITY | THE REGENTS OF THE UNIVERSITY OF COLORADO (US) | 2012-01-26 | — | — | US | claimed |
| EP-2190291-A1 | HSP90 INHIBITORS WITH MODIFIED TOXICITY | The Regents of the University of Colorado (US) | 2010-06-02 | — | — | EP | claimed |
| US-7608611-B2 | Hsp90 inhibitors, methods of making and uses therefor | THE REGENTS OF THE UNIVERSITY OF COLORADO (US) | 2009-10-27 | — | — | US | claimed |
| EP-1863769-A4 | HSP90 INHIBITORS, METHODS OF MAKING AND USES THEREFOR | UNIV COLORADO (US) | 2009-03-18 | — | — | EP | claimed |
| WO-2009026548-A1 | HSP90 INHIBITORS WITH MODIFIED TOXICITY | THE REGENTS OF THE UNIVERSITY OF COLORADO (US) | 2009-02-26 | — | — | WO | claimed |
| EP-1863769-A2 | HSP90 INHIBITORS, METHODS OF MAKING AND USES THEREFOR | The Board of Regents of the University of Colorado (US) | 2007-12-12 | — | — | EP | claimed |
| WO-2006098761-A2 | HSP90 INHIBITORS, METHODS OF MAKING AND USES THEREFOR | THE REGENTS OF THE UNIVERSITY OF COLORADO (US) | 2006-09-21 | — | — | WO | claimed |
| US-20060205705-A1 | Hsp90 inhibitors, methods of making and uses therefor | UNIVERSITY OF COLORADO (US) | 2006-09-14 | — | — | US | claimed |
| EP-0692497-B1 | Method for forming (meth)acrolein-containing polymers | ROHM & HAAS (US) | 1998-07-29 | — | — | EP | claimed |
| EP-0692497-A1 | Method for forming (meth)acrolein-containing polymers | ROHM AND HAAS COMPANY (US) | 1996-01-17 | — | — | EP | claimed |
| US-5412041-A | Hydrolysis of acetal derivative | ROHM AND HAAS COMPANY (US) | 1995-05-02 | — | — | US | claimed |
| US-20230174456-A1 | PROCESS FOR PRODUCING HYDROXYALKYL (METH)ACRYLATE ESTERS BY OXIDATIVE CLEAVAGE OF METHACROLEIN ACETALS | RÖHM GMBH (DE) | 2023-06-08 | — | — | US | disclosed |
| EP-4143154-A1 | METHOD FOR PRODUCING HYDROXYALKYL(METH)ACRYLIC ACID ESTERS BY OXIDATIVE SPLITTING OF METHACROLEIN ACETALS | Röhm GmbH (DE) | 2023-03-08 | — | — | EP | disclosed |
| EP-0692497-A1 | Method for forming (meth)acrolein-containing polymers | ROHM AND HAAS COMPANY (US) | 1996-01-17 | — | — | EP | disclosed |
| US-5412041-A | Hydrolysis of acetal derivative | ROHM AND HAAS COMPANY (US) | 1995-05-02 | — | — | US | disclosed |