SCHEMBL4145808

SCHEMBL4145808

O=C(NC1(CO)CCCC1)c1ccnc2[nH]c(-c3ccc(F)cc3)nc12

nearest known ligand 0.42

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 4/20 0.42
GSK3B P49841 9/20 0.41
CNR1 P21554 2/20 0.37
APOL1 O14791 2/20 0.37
DGAT2 Q96PD7 1/20 0.35
TRPV3 Q8NET8 1/20 0.35
MET P08581 1/20 0.35
AXL P30530 1/20 0.35
TYRO3 Q06418 1/20 0.35
MERTK Q12866 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4164560 0.84 RAD52 (0.42) CNR2GSK3B
SCHEMBL4159185 0.79 GSK3B (0.40) CNR2GSK3BCNR1
SCHEMBL4152905 0.78 CNR2 (0.47) CNR2GSK3BCNR1
SCHEMBL4160333 0.77 PBK (0.47) CNR2GSK3BCNR1
SCHEMBL8236212 0.76 CXCR2 (0.37) CNR2GSK3BCNR1
SCHEMBL4157107 0.76 DHODH (0.49) GSK3B
SCHEMBL13778127 0.76 CNR1 (0.43) CNR2GSK3BCNR1METAXL
SCHEMBL4152713 0.76 SYK (0.43) CNR2GSK3BCNR1
SCHEMBL4160372 0.76 GSK3B (0.42) CNR2GSK3BCNR1
SCHEMBL4152141 0.76 NPC1 (0.48) CNR2CNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090170847-A1 Imidazopyridine Derivatives Inhibiting Protein Kinase Activity, Method for the Preparation Thereof and Pharmaceutical Composition Containing Same YUYU PHARMA, INC. (KR) 2009-07-02 US claimed
EP-1984370-A1 IMIDAZOPYRIDINE DERIVATIVES INHIBITING PROTEIN KINASE ACTIVITY, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING SAME Crystalgenomics, Inc. (KR) 2008-10-29 EP claimed
WO-2007083978-A1 IMIDAZOPYRIDINE DERIVATIVES INHIBITING PROTEIN KINASE ACTIVITY, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING SAME CRYSTALGENOMICS, INC. (KR) 2007-07-26 WO claimed
US-20090170847-A1 Imidazopyridine Derivatives Inhibiting Protein Kinase Activity, Method for the Preparation Thereof and Pharmaceutical Composition Containing Same YUYU PHARMA, INC. (KR) 2009-07-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090170847-A1 Imidazopyridine Derivatives Inhibiting Protein Kinase Activity, Method for the Preparation Thereof and Pharmaceutical Composition Containing Same GSK3B, GSK3A, MAP3K3 CNR2 4327/4885GSK3B 1/4885CNR1 4586/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.