Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP1 | P24666 | 1/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 6/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | PKM | P14618 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.54 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.54 |
| ▸ | PPARG | P37231 | 1/20 | 0.53 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL175217 | 0.81 | ADORA2A (0.68) | ACP1EPHX2HSD17B10RAB9ANPC1 | |
| Bromide SCHEMBL27891199 | 0.79 | ADORA2A (0.67) | ACP1EPHX2HSD17B10RAB9ANPC1 | |
| SCHEMBL10666660 | 0.79 | ACP1 (0.61) | ACP1EPHX2HSD17B10RAB9ANPC1 | |
| SCHEMBL2837504 | 0.79 | ACP1 (0.65) | ACP1EPHX2HSD17B10RAB9ANPC1 | |
| SCHEMBL2837501 | 0.79 | ACP1 (0.65) | ACP1EPHX2HSD17B10RAB9ANPC1 | |
| SCHEMBL4112093 | 0.78 | ADORA2A (0.70) | ACP1RAB9ANPC1PKMSMN1; SMN2 | |
| SCHEMBL14817493 | 0.78 | ACP1 (0.59) | ACP1EPHX2HSD17B10RAB9ANPC1 | |
| SCHEMBL11311757 | 0.78 | ACP1 (0.59) | ACP1EPHX2HSD17B10RAB9ANPC1 | |
| SCHEMBL2605748 | 0.78 | ACP1 (0.55) | ACP1EPHX2HSD17B10RAB9ANPC1 | |
| SCHEMBL11312790 | 0.77 | ACP1 (0.63) | ACP1EPHX2HSD17B10RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120022068-A1 | NOVEL HETEROCYCLIC NF-kB INHIBITORS | 4SC AG (DE) | 2012-01-26 | — | — | US | disclosed |
| US-20100267717-A1 | Novel Heterocyclic NF-kB Inhibitors | 4SC AG (DE) | 2010-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267717-A1 | Novel Heterocyclic NF-kB Inhibitors | NFKB2, NFKBIA, NFRKB | ACP1 3789/4885EPHX2 994/4885HSD17B10 1169/4885 |
| US-20120022068-A1 | NOVEL HETEROCYCLIC NF-kB INHIBITORS | NFKB2, NFKBIA, NFRKB | ACP1 3789/4885EPHX2 994/4885HSD17B10 1169/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.