Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 17/20 | 0.81 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.63 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.63 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.63 |
| ▸ | RAD52 | P43351 | 1/20 | 0.61 |
| ▸ | GFER | P55789 | 1/20 | 0.61 |
| ▸ | KDM1A | O60341 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4157227 | 0.91 | MAPKAPK2 (0.78) | MAPKAPK2ADRA2AADRA2BADRA2CRAD52 | |
| SCHEMBL4150035 | 0.90 | MAPKAPK2 (1.00) | MAPKAPK2ADRA2AADRA2BADRA2CRAD52 | |
| SCHEMBL4155405 | 0.89 | MAPKAPK2 (0.83) | MAPKAPK2ADRA2AADRA2BADRA2CRAD52 | |
| SCHEMBL4156271 | 0.89 | MAPKAPK2 (0.84) | MAPKAPK2ADRA2AADRA2BADRA2CRAD52 | |
| SCHEMBL4149672 | 0.89 | MAPKAPK2 (1.00) | MAPKAPK2ADRA2AADRA2BADRA2CRAD52 | |
| SCHEMBL4152101 | 0.89 | MAPKAPK2 (1.00) | MAPKAPK2ADRA2AADRA2BADRA2CRAD52 | |
| SCHEMBL4141098 | 0.88 | MAPKAPK2 (0.82) | MAPKAPK2ADRA2AADRA2BADRA2CRAD52 | |
| SCHEMBL4141126 | 0.87 | MAPKAPK2 (0.96) | MAPKAPK2ADRA2AADRA2BADRA2CRAD52 | |
| SCHEMBL4151597 | 0.86 | MAPKAPK2 (0.64) | MAPKAPK2ADRA2AADRA2BADRA2CRAD52 | |
| SCHEMBL4138077 | 0.86 | MAPKAPK2 (0.81) | MAPKAPK2ADRA2AADRA2BADRA2CRAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7452887-B2 | Quinoline- and isoquinoline-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof | AMPHORA DISCOVERY CORPORATION (US) | 2008-11-18 | — | — | US | claimed |
| US-20090069338-A1 | Method for predicting skin sensitizing activity of compounds | DICKSON JR JOHN K | 2009-03-12 | — | — | US | disclosed |
| US-7452887-B2 | Quinoline- and isoquinoline-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof | AMPHORA DISCOVERY CORPORATION (US) | 2008-11-18 | — | — | US | disclosed |
| EP-1781293-A1 | QUINOLINE- AND ISOQUINOLINE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | Amphora Discovery Corporation (US) | 2007-05-09 | — | — | EP | disclosed |
| US-20060009460-A1 | Quinoline- and isoquinoline-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof | AGRIUS GROUP, LLC. | 2006-01-12 | — | — | US | disclosed |
| WO-2005120509-A1 | QUINOLINE- AND ISOQUINOLINE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069338-A1 | Method for predicting skin sensitizing activity of compounds | ATP5ME, ABCG2, ATP5MG | MAPKAPK2 2584/4885ADRA2A 1271/4885ADRA2B 1112/4885 |
| US-20060009460-A1 | Quinoline- and isoquinoline-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof | ATP5ME, ATP5MG, ATP5MK | MAPKAPK2 3066/4885ADRA2A 1397/4885ADRA2B 1336/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.