⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16716218 | 0.69 | — | — | |
| SCHEMBL13186160 | 0.69 | — | — | |
| SCHEMBL16716205 | 0.67 | — | — | |
| SCHEMBL8214814 | 0.60 | GAA (0.37) | — | |
| SCHEMBL31266330 | 0.60 | — | — | |
| SCHEMBL393019 | 0.60 | — | — | |
| SCHEMBL4981252 | 0.60 | — | — | |
| SCHEMBL11557266 | 0.58 | GAA (0.36) | — | |
| SCHEMBL25345692 | 0.56 | — | — | |
| SCHEMBL22533257 | 0.56 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8716318-B2 | Pyridone sulfonamides and pyridone sulfamides as MEK inhibitors | ARDEA BIOSCIENCES (US) | 2014-05-06 | — | — | US | disclosed |
| US-8716318-B2 | Pyridone sulfonamides and pyridone sulfamides as MEK inhibitors | ARDEA BIOSCIENCES (US) | 2014-05-06 | — | — | US | disclosed |
| US-8673919-B2 | Dihydropyridin sulfonamides and dihydropyridin sulfamides as MEK inhibitors | ARDEA BIOSCIENCES, INC. (US) | 2014-03-18 | — | — | US | disclosed |
| US-8673919-B2 | Dihydropyridin sulfonamides and dihydropyridin sulfamides as MEK inhibitors | ARDEA BIOSCIENCES, INC. (US) | 2014-03-18 | — | — | US | disclosed |
| US-20120107307-A1 | DIHYDROPYRIDIN SULFONAMIDES AND DIHYDROPYRIDIN SULFAMIDES AS MEK INHIBITORS | ARDEA BIOSCIENCES INC. (US) | 2012-05-03 | — | — | US | disclosed |
| US-20120107307-A1 | DIHYDROPYRIDIN SULFONAMIDES AND DIHYDROPYRIDIN SULFAMIDES AS MEK INHIBITORS | ARDEA BIOSCIENCES INC. (US) | 2012-05-03 | — | — | US | disclosed |
| US-20110112152-A1 | PYRIDONE SULFONAMIDES AND PYRIDONE SULFAMIDES AS MEK INHIBITORS | BAUSCH & LOMB MEXICO, S.A. DE C.V. (MX) | 2011-05-12 | — | — | US | disclosed |
| US-20110112152-A1 | PYRIDONE SULFONAMIDES AND PYRIDONE SULFAMIDES AS MEK INHIBITORS | BAUSCH & LOMB MEXICO, S.A. DE C.V. (MX) | 2011-05-12 | — | — | US | disclosed |
| US-7897624-B2 | Pyridone sulfonamides and pyridone sulfamides as MEK inhibitors | ARDEA BIOSCIENCES (US) | 2011-03-01 | — | — | US | disclosed |
| US-7897624-B2 | Pyridone sulfonamides and pyridone sulfamides as MEK inhibitors | ARDEA BIOSCIENCES (US) | 2011-03-01 | — | — | US | disclosed |
| EP-2012786-B1 | PYRIDONE SULFONAMIDES AND PYRIDONE SULFAMIDES AS MEK INHIBITORS | ARDEA BIOSCIENCES INC (US) | 2010-10-06 | — | — | EP | disclosed |
| US-20070244164-A1 | PYRIDONE SULFONAMIDES AND PYRIDONE SULFAMIDES AS MEK INHIBITORS | ARDEA BIOSCIENCES (US) | 2007-10-18 | — | — | US | disclosed |
| US-20070244164-A1 | PYRIDONE SULFONAMIDES AND PYRIDONE SULFAMIDES AS MEK INHIBITORS | ARDEA BIOSCIENCES (US) | 2007-10-18 | — | — | US | disclosed |