SCHEMBL4150558

SCHEMBL4150558

COc1cccc([C@H]2O[C@H](Cc3ncc(C(C)C(=O)O)o3)C(=O)N(CC(C)C(C)O)c3ccc(Cl)cc32)c1OC

nearest known ligand 0.53

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
FDFT1 P37268 13/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4150559 0.89 FDFT1 (0.53) FDFT1
SCHEMBL4142551 0.89 FDFT1 (0.70) FDFT1
SCHEMBL4933243 0.86 FDFT1 (0.63) FDFT1
SCHEMBL4146004 0.84 FDFT1 (0.56) FDFT1
SCHEMBL4935131 0.80 FDFT1 (0.58) FDFT1
SCHEMBL4936025 0.80 FDFT1 (0.73) FDFT1
SCHEMBL4933225 0.79 FDFT1 (0.57) FDFT1
SCHEMBL4935442 0.78 FDFT1 (0.64) FDFT1
SCHEMBL4105256 0.77 FDFT1 (0.77) FDFT1
SCHEMBL14069983 0.77 FDFT1 (0.73) FDFT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090082333-A1 REMEDY FOR XANTHOMA NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY (JP) 2009-03-26 US disclosed
EP-1889632-A1 REMEDY FOR XANTHOMA National University Corp. Kobe University (JP) 2008-02-20 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090082333-A1 REMEDY FOR XANTHOMA FDFT1, LSS, SQLE FDFT1 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.