Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.82 |
| ▸ | CDK2 | P24941 | 16/20 | 0.72 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.72 |
| ▸ | AURKA | O14965 | 12/20 | 0.69 |
| ▸ | AURKB | Q96GD4 | 11/20 | 0.69 |
| ▸ | CDK4 | P11802 | 11/20 | 0.69 |
| ▸ | CDK9 | P50750 | 11/20 | 0.67 |
| ▸ | CDK7 | P50613 | 7/20 | 0.67 |
| ▸ | CDK1 | P06493 | 6/20 | 0.67 |
| ▸ | WEE1 | P30291 | 5/20 | 0.58 |
| ▸ | FLT3 | P36888 | 4/20 | 0.58 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.58 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.58 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.58 |
| ▸ | JAK2 | O60674 | 3/20 | 0.58 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.58 |
| ▸ | PAK4 | O96013 | 3/20 | 0.58 |
| ▸ | ABL1 | P00519 | 3/20 | 0.58 |
| ▸ | FYN | P06241 | 3/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4168788 | 0.91 | GSK3B (0.88) | GSK3BCDK2CCNE1AURKAAURKB | |
| SCHEMBL2077092 | 0.90 | GSK3B (1.00) | GSK3BCDK2CCNE1AURKAAURKB | |
| SCHEMBL4160054 | 0.89 | GSK3B (0.84) | GSK3BCDK2CCNE1AURKAAURKB | |
| SCHEMBL4165464 | 0.87 | GSK3B (0.81) | GSK3BCDK2CCNE1AURKAAURKB | |
| SCHEMBL2075743 | 0.85 | CDK2 (0.78) | GSK3BCDK2CCNE1AURKAAURKB | |
| SCHEMBL2086730 | 0.85 | GSK3B (0.70) | GSK3BCDK2CCNE1AURKAAURKB | |
| SCHEMBL4166368 | 0.85 | CDK2 (0.74) | GSK3BCDK2CCNE1AURKAAURKB | |
| SCHEMBL2075987 | 0.84 | CDK2 (1.00) | GSK3BCDK2CCNE1AURKAAURKB | |
| SCHEMBL6209137 | 0.84 | CDK2 (0.74) | GSK3BCDK2CCNE1AURKAAURKB | |
| SCHEMBL4165439 | 0.84 | CDK2 (0.84) | GSK3BCDK2CCNE1AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137572-A1 | 2-substituted-4-heteroaryl-pyrimidines useful for the treatment of proliferative disorders | CYCLACEL LIMITED (GB) | 2009-05-28 | — | — | US | claimed |
| EP-1756098-A2 | 2-SUBSTITUTED-4-HETEROARYL-PYRIMIDINES USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | Cyclacel Limited (GB) | 2007-02-28 | — | — | EP | claimed |
| WO-2005116025-A2 | 2-SUBSTITUTED-4-HETEROARYL-PYRIMIDINES USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | CYCLACEL LIMITED (GB) | 2005-12-08 | — | — | WO | claimed |
| US-20090137572-A1 | 2-substituted-4-heteroaryl-pyrimidines useful for the treatment of proliferative disorders | CYCLACEL LIMITED (GB) | 2009-05-28 | — | — | US | disclosed |
| US-20090137572-A1 | 2-substituted-4-heteroaryl-pyrimidines useful for the treatment of proliferative disorders | CYCLACEL LIMITED (GB) | 2009-05-28 | — | — | US | disclosed |
| US-20090137572-A1 | 2-substituted-4-heteroaryl-pyrimidines useful for the treatment of proliferative disorders | CYCLACEL LIMITED (GB) | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137572-A1 | 2-substituted-4-heteroaryl-pyrimidines useful for the treatment of proliferative disorders | CDK2, CDK4, CDK20 | GSK3B 829/4885CDK2 1/4885CCNE1 97/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.