Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | GPR132 | Q9UNW8 | 2/20 | 0.36 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4155762 | 1.00 | PRMT5 (0.37) | PRMT5WDR77GPR84HRH3GPR132 | |
| SCHEMBL4153355 | 0.92 | HRH3 (0.39) | HRH3NPC1RAB9AMRGPRX4POLB | |
| SCHEMBL4153354 | 0.92 | HRH3 (0.39) | HRH3NPC1RAB9AMRGPRX4POLB | |
| SCHEMBL4157400 | 0.92 | NPC1 (0.36) | PRMT5WDR77GPR84HRH3SLC6A5 | |
| SCHEMBL4157401 | 0.92 | NPC1 (0.36) | PRMT5WDR77GPR84HRH3SLC6A5 | |
| SCHEMBL4144488 | 0.91 | PRMT5 (0.38) | PRMT5WDR77GPR84HRH3GPR132 | |
| SCHEMBL4144490 | 0.91 | PRMT5 (0.38) | PRMT5WDR77GPR84HRH3GPR132 | |
| SCHEMBL4139614 | 0.90 | PRMT5 (0.36) | PRMT5WDR77GPR84HRH3GPR132 | |
| SCHEMBL4139612 | 0.90 | PRMT5 (0.36) | PRMT5WDR77GPR84HRH3GPR132 | |
| SCHEMBL4149796 | 0.90 | PRMT5 (0.39) | PRMT5WDR77GPR84HRH3SLC6A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090136449-A1 | Tetracyclic Indole Derivatives as Antiviral Agents | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2009-05-28 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090136449-A1 | Tetracyclic Indole Derivatives as Antiviral Agents | IDO1, IDO2, ZC3HAV1 | PRMT5 3377/4885WDR77 3311/4885GPR84 2204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.