SCHEMBL4157216

SCHEMBL4157216

Cc1oc(-c2ccccc2)nc1CCOc1ccc(C(CC(=O)O)Nc2ccccc2C(=O)c2ccccc2)cc1

nearest known ligand 0.72

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PPARG P37231 20/20 0.72
PPARA Q07869 3/20 0.72
PPARD Q03181 1/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4396945 1.00 PPARG (0.72) PPARGPPARAPPARD
SCHEMBL6612891 0.92 PPARG (0.69) PPARGPPARAPPARD
SCHEMBL6611075 0.88 PPARG (0.70) PPARGPPARAPPARD
SCHEMBL6612058 0.87 PPARG (0.69) PPARGPPARAPPARD
SCHEMBL6608996 0.87 PPARG (0.68) PPARGPPARAPPARD
SCHEMBL6608390 0.86 PPARG (0.67) PPARGPPARAPPARD
SCHEMBL6611004 0.86 PPARG (0.67) PPARGPPARAPPARD
SCHEMBL5971527 0.86 PPARG (0.59) PPARGPPARAPPARD
SCHEMBL6614464 0.85 PPARG (0.66) PPARGPPARAPPARD
SCHEMBL6614266 0.85 PPARG (0.66) PPARGPPARAPPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6436993-B1 SYNERGISTIC MIXTURES OF RETINOIC ACID RECEPTOR (RAR) ANTAGONISTS AND STEROID, THYROID OR RETINOID RECEPTOR AGONISTS SUCH AS PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS USED TO CONTROL CELLULAR PROCESSES THE SALK INSTITUTE FOR BIOLOGICAL STUDIES 2002-08-20 US claimed
US-6291496-B1 E.G., WITH OVEREXPRESSSION OF HER-2/NEU OR OVEREXPRESSION OF EPIDERMAL GROWTH FACTOR RECEPTOR, ARE TREATED WITH STRONGLY BINDING PPAR GAMMA LIGANDS. CORNELL RESEARCH FOUNDATION, INC. 2001-09-18 US claimed
WO-2001047555-A1 TREATING CANCERS ASSOCIATED WITH OVEREXPRESSION OF CLASS I FAMILY OF RECEPTOR TYROSINE KINASES CORNELL RESEARCH FOUNDATION, INC. (US) 2001-07-05 WO claimed
EP-2081599-A2 COMPOUNDS, KITS AND METHODS FOR CONFERRING CYTOPROTECTION University of Debrecen (HU) 2009-07-29 EP disclosed
US-20090155228-A1 COMPOUNDS, KITS AND METHODS FOR CONFERRING CYTOPROTECTION UNIVERSITY OF DEBRECEN (HU) 2009-06-18 US disclosed
WO-2007144679-A2 COMPOUNDS, KITS AND METHODS FOR CONFERRING CYTOPROTECTION UNIVERSITY OF DEBRECEN (HU) 2007-12-21 WO disclosed
WO-2006044961-A1 PPAR-GAMMA MODULATORES SMITHKLINE BEECHAM CORPORATION (US) 2006-04-27 WO disclosed
EP-1210345-B1 OXAZOLE PPAR ANTAGONISTS GLAXO GROUP LTD (GB) 2004-03-03 EP disclosed
US-6506781-B1 Prevent formation of a hydrogen bond between the agonist and tyrosine or histidine, or tryptophan involved in receptor activation; and/or b) displace the tyrosine or histidine, or tryptophan involved in receptor activation from its agonist SMITHKLINE BEECHAM CORPORATION 2003-01-14 US disclosed
US-6436993-B1 SYNERGISTIC MIXTURES OF RETINOIC ACID RECEPTOR (RAR) ANTAGONISTS AND STEROID, THYROID OR RETINOID RECEPTOR AGONISTS SUCH AS PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS USED TO CONTROL CELLULAR PROCESSES THE SALK INSTITUTE FOR BIOLOGICAL STUDIES 2002-08-20 US disclosed
EP-1210345-A1 OXAZOLE PPAR ANTAGONISTS GLAXO GROUP LIMITED (GB) 2002-06-05 EP disclosed
US-6291496-B1 E.G., WITH OVEREXPRESSSION OF HER-2/NEU OR OVEREXPRESSION OF EPIDERMAL GROWTH FACTOR RECEPTOR, ARE TREATED WITH STRONGLY BINDING PPAR GAMMA LIGANDS. CORNELL RESEARCH FOUNDATION, INC. 2001-09-18 US disclosed
WO-2001047555-A1 TREATING CANCERS ASSOCIATED WITH OVEREXPRESSION OF CLASS I FAMILY OF RECEPTOR TYROSINE KINASES CORNELL RESEARCH FOUNDATION, INC. (US) 2001-07-05 WO disclosed
WO-2001017994-A1 OXAZOLE PPAR ANTAGONISTS GLAXO GROUP LIMITED (GB) 2001-03-15 WO disclosed