SCHEMBL4158554

SCHEMBL4158554

NS(=O)(=O)c1ccccc1[N+](=O)[O-]

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.70
MEN1 O00255 3/20 0.70
CA2 P00918 4/20 0.59
CA1 P00915 3/20 0.59
MMP1 P03956 1/20 0.59
MMP2 P08253 1/20 0.59
MMP9 P14780 1/20 0.59
MMP8 P22894 1/20 0.59
MMP13 P45452 1/20 0.59
F2 P00734 3/20 0.59
PRSS1 P07477 3/20 0.59
PRSS2 P07478 3/20 0.59
PRSS3 P35030 3/20 0.59
CA9 Q16790 2/20 0.54
CA4 P22748 2/20 0.54
CA6 P23280 2/20 0.54
CA12 O43570 1/20 0.54
CYP2C9 P11712 1/20 0.54
CA5A P35218 1/20 0.54
CA7 P43166 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL370668 1.00 KMT2A (0.70) KMT2AMEN1CA2CA1MMP1
Hydrochloric Acid SCHEMBL28910568 0.98 KMT2A (0.68) KMT2AMEN1CA2CA1MMP1
SCHEMBL29889311 0.98 KMT2A (0.68) KMT2AMEN1CA2CA1MMP1
SCHEMBL22719534 0.98 KMT2A (0.68) KMT2AMEN1CA2CA1MMP1
Acetic Acid SCHEMBL29097243 0.89 KMT2A (0.58) KMT2AMEN1CA2CA1MMP1
SCHEMBL30648996 0.86 KMT2A (0.63) KMT2AMEN1CA2CA1MMP1
SCHEMBL2039879 0.83 KMT2A (1.00) KMT2AMEN1CA2CA1MMP1
SCHEMBL11566827 0.83 KMT2A (1.00) KMT2AMEN1CA2CA1MMP1
SCHEMBL30446303 0.83 KMT2A (1.00) KMT2AMEN1CA2CA1MMP1
SCHEMBL7531976 0.82 KMT2A (0.53) KMT2AMEN1CA2CA1MMP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12576029-B2 Noncompetitive receptor-targeted vaccine delivery to plasmacytoid dendritic cells WASHINGTON UNIVERSITY (US) 2026-03-17 US disclosed
WO-2025053947-A1 SYNTHETIC TRITERPENES COMPOSITION, METHOD OF PRODUCTION AND APPLICATIONS THEREOF AVANTOR PERFORMANCE MATERIALS, LLC (US) 2025-03-13 WO disclosed
EP-4419513-A1 ANTITUMORAL COMPOUNDS Pharma Mar S.A. (ES) 2024-08-28 EP disclosed
WO-2024081775-A1 SYNTHESIS OF 6-FLUORO-2-METHYLBENZO[D]THIAZOL-5-YL COMPOUNDS ELI LILLY AND COMPANY (US) 2024-04-18 WO disclosed
CN-111936468-B Compounds with anticancer activity 协和麒麟株式会社 2024-03-08 CN disclosed
US-20240024238-A1 NONCOMPETITIVE RECEPTOR-TARGETED VACCINE DELIVERY TO PLASMACYTOID DENDRITIC CELLS WASHINGTON UNIVERSITY ST LOUIS (US) 2024-01-25 US disclosed
EP-4291328-A1 DIRUTHENIUM CATALYST COMPOSITIONS AND SYNTHETIC PROCESSES RELATED THERETO Emory University (US) 2023-12-20 EP disclosed
WO-2023219952-A1 MELANOCORTIN TYPE 2 RECEPTOR (MC2R) TARGETED THERAPEUTICS AND USES THEREOF RADIONETICS ONCOLOGY, INC. (US) 2023-11-16 WO disclosed
CN-116981672-A Macrocyclic compounds as CFTR modulators 爱杜西亚药品有限公司 2023-10-31 CN disclosed
EP-2435432-B3 APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES ABBVIE IRELAND UNLIMITED CO (BM) 2023-10-25 EP disclosed
US-20130252341-A1 METHOD AND DEVICE FOR DETECTING NUCLEIC ACID, AND KIT KANEKA CORPORATION (JP) 2013-09-26 US disclosed
EP-2620508-A1 METHOD AND DEVICE FOR DETECTING NUCLEIC ACID, AND KIT Kaneka Corporation (JP) 2013-07-31 EP disclosed
US-20090088438-A1 NEW TYROSINE DERIVATIVES AS PPARy MODULATORS LABORATORIOS SALVAT, S.A. (ES) 2009-04-02 US disclosed
US-7423172-B2 Tyrosine derivatives as PPAR-γ-modulators LABORATORIOS SALVAT, S.A. (ES) 2008-09-09 US disclosed
EP-1778624-B1 TYROSINE DERIVATIVES AS PPAR-GAMMA-MODULATORS SALVAT LAB SA (ES) 2008-08-20 EP disclosed
US-20070276043-A1 Tyrosine Derivatives As Ppar-Gamma-Modulators LABORATORIES SALVAT, S.A. (ES) 2007-11-29 US disclosed
EP-1778624-A1 TYROSINE DERIVATIVES AS PPAR-GAMMA-MODULATORS Laboratorios SALVAT, S.A. (ES) 2007-05-02 EP disclosed
WO-2006010775-A1 TYROSINE DERIVATIVES AS PPAR-GAMMA-MODULATORS LABORATORIOS SALVAT, S.A. (ES) 2006-02-02 WO disclosed
US-20050153408-A1 7-substituted-2-tetralone or bisulfite adduct is reduced microorganism (Candida) to optically active 7-substituted-2-tetralol;sulfonyl group is introduced to hydroxy group to form optically active 7-substituted-2-sulfonyloxytetralin; nitrogen substituent is introduced via ammonia; industrial scale KANEKA CORPORATION (JP) 2005-07-14 US disclosed
EP-1457570-A1 PROCESS FOR PREPARATION OF 2-AMINOTETRALIN DERIVATIVES AND INTERMEDIATES THEREOF KANEKA CORPORATION (JP) 2004-09-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090088438-A1 NEW TYROSINE DERIVATIVES AS PPARy MODULATORS PPARG, PPARD, TYRO3 KMT2A 2852/4885MEN1 4879/4885CA2 4026/4885
US-20240024238-A1 NONCOMPETITIVE RECEPTOR-TARGETED VACCINE DELIVERY TO PLASMACYTOID DENDRITIC CELLS HAVCR2, CD4, CD44 KMT2A 4441/4885MEN1 4673/4885CA2 4088/4885
US-12576029-B2 Noncompetitive receptor-targeted vaccine delivery to plasmacytoid dendritic cells DGKG, PHOSPHO1, TLR3 KMT2A 4019/4885MEN1 4492/4885CA2 3036/4885
US-20070276043-A1 Tyrosine Derivatives As Ppar-Gamma-Modulators PPARG, PPARD, PPARA KMT2A 2792/4885MEN1 4879/4885CA2 3888/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.