Sugi Predict

Sugi Predict / Compounds / SCHEMBL4160448

SCHEMBL4160448

SCHEMBL4160448

Cc1cc(Nc2cnc(C(=O)NCC(N)=O)c(Nc3ccc(Cl)cc3)n2)n[nH]1

nearest known ligand 0.45

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ RET P07949 7/20 0.45
▸ AURKA O14965 5/20 0.40
▸ EGLN1 Q9GZT9 1/20 0.40
▸ EGLN3 Q9H6Z9 1/20 0.40
▸ PAK4 O96013 2/20 0.39
▸ SYK P43405 2/20 0.39
▸ PLK4 O00444 1/20 0.39
▸ MEN1 O00255 1/20 0.39
▸ HTT P42858 1/20 0.39
▸ KMT2A Q03164 1/20 0.39
▸ HSD17B10 Q99714 1/20 0.39
▸ NPC1 O15118 1/20 0.39
▸ RAB9A P51151 1/20 0.39
▸ AURKB Q96GD4 2/20 0.38
▸ CSNK2A1 P68400 1/20 0.38
▸ NTRK1 P04629 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4176412 0.89 RET (0.45) RETAURKAPAK4SYKPLK4
SCHEMBL4304592 0.88 RET (0.47) RETAURKAPAK4SYKPLK4
SCHEMBL4171606 0.87 AURKA (0.44) RETAURKAPAK4SYKPLK4
SCHEMBL4175466 0.87 RET (0.45) RETAURKAPAK4SYKPLK4
SCHEMBL4012876 0.87 RET (0.45) RETAURKAPAK4SYKPLK4
SCHEMBL4173212 0.86 RET (0.44) RETAURKAPAK4SYKPLK4
SCHEMBL4178714 0.84 CSNK2A1 (0.45) RETAURKAPAK4SYKPLK4
SCHEMBL4170177 0.84 RET (0.40) RETAURKAPAK4SYKPLK4
SCHEMBL4017086 0.83 PAK4 (0.56) RETAURKAPAK4SYKMEN1
SCHEMBL4169017 0.83 PAK4 (0.46) RETAURKAPAK4PLK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090270418-A1 PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH SIGNAL PHARMACEUTICALS, LLC 2009-10-29 — — US claimed
WO-2009089042-A1 PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH SIGNAL PHARMACEUTICALS, LLC (US) 2009-07-16 — — WO claimed
US-20090270418-A1 PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH SIGNAL PHARMACEUTICALS, LLC 2009-10-29 — — US disclosed
US-20090270418-A1 PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH SIGNAL PHARMACEUTICALS, LLC 2009-10-29 — — US disclosed
US-20090270418-A1 PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH SIGNAL PHARMACEUTICALS, LLC 2009-10-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090270418-A1 PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH MAP3K1, MAP3K15, MAP3K5 RET 370/4885AURKA 408/4885EGLN1 2885/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.