Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 8/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.49 |
| ▸ | BACE1 | P56817 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | EPHB3 | P54753 | 2/20 | 0.43 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4793267 | 0.74 | HDAC6 (0.63) | HDAC6HDAC1HDAC4HDAC3EPHX2 | |
| SCHEMBL17707613 | 0.73 | HDAC6 (1.00) | HDAC6HDAC1HDAC4HDAC3 | |
| SCHEMBL15886363 | 0.73 | BACE1 (0.61) | EPHX2BACE1KDM4EALDH1A1NPC1 | |
| SCHEMBL2204320 | 0.72 | HDAC6 (0.70) | HDAC6HDAC1HDAC4HDAC3EPHX2 | |
| Trifluoroacetic Acid SCHEMBL2203009 | 0.72 | HDAC1 (0.71) | HDAC6HDAC1HDAC4HDAC3ALDH1A1 | |
| SCHEMBL2202013 | 0.72 | HDAC1 (1.00) | HDAC6HDAC1HDAC4HDAC3EPHX2 | |
| SCHEMBL4160887 | 0.71 | HDAC6 (0.53) | HDAC6HDAC1HDAC4HDAC3EPHX2 | |
| SCHEMBL15883344 | 0.71 | BACE1 (0.58) | EPHX2BACE1KDM4EALDH1A1NPC1 | |
| Trifluoroacetic Acid SCHEMBL2201672 | 0.70 | HDAC1 (0.64) | HDAC6HDAC1HDAC4HDAC3 | |
| Trifluoroacetic Acid SCHEMBL4178131 | 0.70 | HDAC6 (0.55) | HDAC6HDAC1HDAC4HDAC3DGAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1926721-B1 | THIOPHENE AND THIAZOLE SUBSTITUTED TRIFLUOROETHANONE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | MSD ITALIA SRL (IT) | 2016-05-04 | — | — | EP | claimed |
| EP-1926721-B1 | THIOPHENE AND THIAZOLE SUBSTITUTED TRIFLUOROETHANONE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | MSD ITALIA SRL (IT) | 2016-05-04 | — | — | EP | disclosed |
| US-20090156591-A1 | Thiophene and Thiazole Substituted trifluoroethanone Derivatives as Histone Deacetylase (Hdac) Inhibitors | MSD ITALIA S.R.L. (IT) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156591-A1 | Thiophene and Thiazole Substituted trifluoroethanone Derivatives as Histone Deacetylase (Hdac) Inhibitors | HDAC1, HDAC2, HDAC11 | HDAC6 6/4885HDAC1 1/4885HDAC4 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.