Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4154197 | 0.87 | HDAC1 (0.37) | CES1HDAC1HDAC2L3MBTL1LMNA | |
| SCHEMBL4171428 | 0.86 | CES1 (0.44) | CES1HDAC1HDAC2 | |
| SCHEMBL3507608 | 0.85 | CES1 (0.36) | CES1HDAC1HDAC2MEN1KMT2A | |
| SCHEMBL4173034 | 0.79 | CES1 (0.33) | CES1HDAC1HDAC2POLB | |
| SCHEMBL4158958 | 0.77 | CYP1A2 (0.41) | MEN1POLBKMT2A | |
| Trifluoroacetic Acid SCHEMBL4159827 | 0.74 | BCHE (0.42) | CES1MEN1KMT2A | |
| SCHEMBL4164039 | 0.74 | HDAC1 (0.41) | CES1HDAC1HDAC2MEN1POLB | |
| SCHEMBL4165147 | 0.73 | CES1 (0.43) | CES1HDAC1HDAC2LMNA | |
| Trifluoroacetic Acid SCHEMBL4156516 | 0.73 | CES1 (0.31) | CES1 | |
| SCHEMBL4160414 | 0.72 | CES1 (0.35) | CES1HDAC1HDAC2POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090054448-A1 | Amino Acid Derivatives as Histone Deacetylase (HDAC) Inhibitors | JONES PHILIP | 2009-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054448-A1 | Amino Acid Derivatives as Histone Deacetylase (HDAC) Inhibitors | HDAC5, HDAC1, HDAC11 | CES1 1925/4885HDAC1 2/4885HDAC2 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.