Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Thalidomide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN known ✓ | Q96SW2 | 19/20 | 1.00 |
| ▸ | DDB1 known ✓ | Q16531 | 13/20 | 1.00 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 1/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | TNF | P01375 | 1/20 | 0.74 |
| ▸ | IL1B | P01584 | 1/20 | 0.74 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.74 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thalidomide SCHEMBL7581 | 1.00 | CRBN (1.00) | CRBNDDB1IKZF3ALDH1A1CHRM2 | |
| Thalidomide SCHEMBL410642 | 1.00 | CRBN (1.00) | CRBNDDB1IKZF3ALDH1A1CHRM2 | |
| Thalidomide SCHEMBL15197560 | 1.00 | CRBN (1.00) | CRBNDDB1IKZF3ALDH1A1CHRM2 | |
| Thalidomide SCHEMBL571278 | 1.00 | CRBN (1.00) | CRBNDDB1IKZF3ALDH1A1CHRM2 | |
| Thalidomide SCHEMBL455269 | 1.00 | CRBN (1.00) | CRBNDDB1IKZF3ALDH1A1CHRM2 | |
| Thalidomide SCHEMBL411178 | 1.00 | CRBN (1.00) | CRBNDDB1IKZF3ALDH1A1CHRM2 | |
| Thalidomide SCHEMBL411175 | 1.00 | CRBN (1.00) | CRBNDDB1IKZF3ALDH1A1CHRM2 | |
| Thalidomide SCHEMBL23420695 | 0.98 | CRBN (0.97) | CRBNDDB1IKZF3ALDH1A1CHRM2 | |
| Thalidomide SCHEMBL22772286 | 0.98 | CRBN (0.97) | CRBNDDB1IKZF3ALDH1A1CHRM2 | |
| Thalidomide SCHEMBL19586750 | 0.98 | CRBN (0.97) | CRBNDDB1IKZF3ALDH1A1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 12506 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260069700-A1 | BRUSH PRODRUGS AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2026-03-12 | — | — | US | claimed |
| US-12564728-B2 | Treatment of central nervous system disorders | KNOW BIO, LLC (US) | 2026-03-03 | — | — | US | claimed |
| US-20260028400-A1 | ANTI-ROR1 ANTIBODY AND USE THEREOF | AIMED BIO INC (KR) | 2026-01-29 | — | — | US | claimed |
| EP-4662203-A1 | BINDARIT CONJUGATES, COMPOSITIONS AND METHODS FOR TREATING OCULAR DISEASES OR DISORDERS | Translatum Medicus Inc. (CA) | 2025-12-17 | — | — | EP | claimed |
| US-20250287942-A1 | FORMULATIONS FOR REPELLING BEES AND OTHER INSECTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2025-09-18 | — | — | US | claimed |
| US-20250242046-A1 | ALLOGENEIC HYPOIMMUNE BIOMIMETIC NANOVESICLE FOR THE TREATMENT OF CANCER | MALCOLM THOMAS (US) | 2025-07-31 | — | — | US | claimed |
| EP-4563597-A1 | ANTI-ROR1 ANTIBODY AND USE THEREOF | AIMED BIO INC. (KR) | 2025-06-04 | — | — | EP | claimed |
| US-20250114653-A1 | COMPOSITIONS, METHODS, AND ARTICLES COMPRISING COCAINE ESTERASE FOR DETOXIFYING AN ORGANOPHOSPHATE-BASED AGENT | FOUR WINDS BIOTHERAPEUTICS, INC. | 2025-04-10 | — | — | US | claimed |
| EP-4532024-A1 | ALLOGENEIC HYPOIMMUNE BIOMIMETIC NANOVESICLE FOR THE TREATMENT OF CANCER | Malcolm, Thomas (US) | 2025-04-09 | — | — | EP | claimed |
| CN-119677539-A | Combination therapy for modulating lipid production | 俄亥俄州创新基金会 | 2025-03-21 | — | — | CN | claimed |
| CN-1215397-A | Acylated N-hydroxymethylthalidomide prodrugs with immunomodulator activity | GRUENENTHAL GMBH (DE) | 1999-04-28 | — | — | CN | claimed |
| WO-1999012886-A1 | METHOD FOR PRODUCING A DINITRONAPHTHALENE-ISOMER MIXTURE WITH A HIGH PROPORTION OF 1,5-DINITRONAPHTHALENE | BAYER AKTIENGESELLSCHAFT (DE) | 1999-03-18 | — | — | WO | claimed |
| WO-1998024320-A1 | HERBICIDES CONTAINING N-[(4,6-DIMETHOXYPYRIMIDINE-2-YL)AMINOCARBONYL]-5-METHYLSULPHONAMIDOMETHYL -2-ALKOXYCARBONYLBENZENE SULPHONAMIDES | HOECHST SCHERING AGREVO GMBH (DE) | 1998-06-11 | — | — | WO | claimed |
| EP-0565706-B1 | WATER-SOLUBLE DELIVERY SYSTEMS FOR HYDROPHOBIC LIQUIDS | FUISZ TECHNOLOGIES LTD (US) | 1997-01-29 | — | — | EP | claimed |
| EP-0697854-A1 | USE OF HYDROXYNAPHTHALENES IN COLOURING AGENTS | HENKEL KGAA (DE) | 1996-02-28 | — | — | EP | claimed |
| WO-1994026241-A1 | USE OF HYDROXYNAPHTHALENES IN COLOURING AGENTS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1994-11-24 | — | — | WO | claimed |
| EP-0340591-A2 | Light-induced dark-hardening adhesives | Henkel Kommanditgesellschaft auf Aktien (DE) | 1989-11-08 | — | — | EP | claimed |
| US-4623540-A | POLYMER, SURFACTANT | LES PRODUITS ORGANIQUES DU SANTERRE-ORSAN S.A. ("ORSAN") (FR) | 1986-11-18 | — | — | US | claimed |
| EP-0140847-A2 | A computer printout and document holding device, formed by composable elements | CARTOPLAST BERTESI S.p.A. (IT) | 1985-05-08 | — | — | EP | claimed |
| US-4470966-A | Controlled release insecticide composition | CELANESE CORPORATION (US) | 1984-09-11 | — | — | US | claimed |