Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | DHFR | P00374 | 2/20 | 0.46 |
| ▸ | HEXA | P06865 | 1/20 | 0.46 |
| ▸ | HEXB | P07686 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | AKT2 | P31751 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | USP7 | Q93009 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23400366 | 0.79 | GRIA2 (0.43) | MAPTDHFRHEXAHEXBPOLB | |
| SCHEMBL15730775 | 0.76 | POLB (0.63) | MAPTLMNAPOLBKDM4ENPC1 | |
| SCHEMBL4163849 | 0.74 | POLB (0.40) | MAPTLMNADHFRHEXAHEXB | |
| SCHEMBL4164612 | 0.69 | POLB (0.46) | MAPTLMNADHFRHEXAHEXB | |
| SCHEMBL23398949 | 0.69 | RECQL (0.47) | MAPTLMNAPOLBCDK8GSK3B | |
| SCHEMBL8041067 | 0.69 | GAA (0.38) | GAAKMT2A | |
| SCHEMBL28281340 | 0.69 | GAA (0.47) | GAAKMT2A | |
| SCHEMBL8041064 | 0.67 | GSK3B (0.46) | MAPTLMNAPOLBCDK8ACVR1 | |
| SCHEMBL23398991 | 0.67 | MAPT (0.39) | MAPTLMNAPOLBCDK8ACVR1 | |
| SCHEMBL1233348 | 0.66 | TLR7 (0.50) | LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044063-A1 | PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | Astra Zeneca AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008001070-A1 | PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-01-03 | — | — | WO | disclosed |