Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 2/20 | 0.57 |
| ▸ | KDR | P35968 | 11/20 | 0.54 |
| ▸ | CSF1R | P07333 | 3/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.52 |
| ▸ | KIF5B | P33176 | 1/20 | 0.52 |
| ▸ | BRAF | P15056 | 3/20 | 0.52 |
| ▸ | RAF1 | P04049 | 2/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.49 |
| ▸ | FLT4 | P35916 | 4/20 | 0.49 |
| ▸ | FLT3 | P36888 | 3/20 | 0.49 |
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4168769 | 0.95 | KDR (0.52) | LCKKDRCSF1RPDGFRARET | |
| SCHEMBL4170739 | 0.95 | KDR (0.52) | LCKKDRCSF1RPDGFRARET | |
| SCHEMBL4175668 | 0.90 | LCK (0.56) | LCKKDRCSF1RPDGFRARET | |
| SCHEMBL4178009 | 0.83 | KDR (0.58) | LCKKDRCSF1RPDGFRARET | |
| SCHEMBL4508946 | 0.82 | PDGFRB (0.61) | KDRCSF1RPDGFRAPDGFRBFLT3 | |
| SCHEMBL1097542 | 0.82 | PDGFRB (0.64) | LCKKDRCSF1RPDGFRARET | |
| SCHEMBL1097832 | 0.81 | PDGFRB (0.67) | KDRCSF1RPDGFRAPDGFRBFLT4 | |
| SCHEMBL4179204 | 0.80 | PDGFRB (0.57) | KDRCSF1RPDGFRABRAFRAF1 | |
| SCHEMBL4179313 | 0.80 | PDGFRB (0.57) | KDRCSF1RPDGFRAPDGFRBFLT4 | |
| SCHEMBL4161085 | 0.80 | PDGFRB (0.77) | KDRCSF1RBRAFRAF1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090233950-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2009-09-17 | — | — | US | disclosed |
| EP-1994023-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007099317-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233950-A1 | QUINAZOLINE DERIVATIVES | NQO2, CCNI, F12 | LCK 1627/4885KDR 2384/4885CSF1R 666/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.