Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 14/20 | 0.52 |
| ▸ | TNKS | O95271 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.35 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.34 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.31 |
| ▸ | NPY1R | P25929 | 1/20 | 0.30 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL604754 | 0.73 | HRH4 (0.56) | HRH4TNKSPARP1TNKS2SSTR5 | |
| SCHEMBL606087 | 0.69 | HRH4 (0.60) | HRH4TNKSPARP1TNKS2CARM1 | |
| SCHEMBL2913640 | 0.68 | HRH4 (1.00) | HRH4TNKSPARP1TNKS2SSTR5 | |
| SCHEMBL2913118 | 0.67 | HRH4 (0.83) | HRH4TNKSPARP1TNKS2SSTR5 | |
| SCHEMBL2906607 | 0.67 | HRH4 (0.83) | HRH4TNKSPARP1TNKS2SSTR5 | |
| SCHEMBL602382 | 0.64 | HRH4 (0.55) | HRH4CARM1SSTR2KCNH2 | |
| SCHEMBL604735 | 0.63 | HRH4 (0.55) | HRH4 | |
| SCHEMBL602644 | 0.63 | HRH4 (0.56) | HRH4 | |
| SCHEMBL605478 | 0.63 | HRH4 (0.53) | HRH4CARM1NPY1RSSTR2KCNH2 | |
| SCHEMBL18824778 | 0.63 | HRH4 (0.65) | HRH4SSTR5SSTR2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8084466-B2 | Bicyclic heteroaryl-substituted imidazoles as modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA NV (BE) | 2011-12-27 | — | — | US | disclosed |
| US-20090156613-A1 | Bicyclic heteroaryl-substituted imidazoles as modulators of the histamine H4 receptor | KINDRACHUK DAVID E | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156613-A1 | Bicyclic heteroaryl-substituted imidazoles as modulators of the histamine H4 receptor | HRH4, HRH3, HRH1 | HRH4 1/4885TNKS 4178/4885PARP1 3485/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.