Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLNR | O43193 | 18/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2765733 | 0.85 | MLNR (0.74) | MLNR | |
| SCHEMBL2766848 | 0.81 | MLNR (0.60) | MLNRCYP3A4 | |
| SCHEMBL2765935 | 0.74 | MLNR (0.78) | MLNR | |
| SCHEMBL2765825 | 0.71 | MLNR (0.69) | MLNR | |
| SCHEMBL2768667 | 0.71 | MLNR (0.55) | MLNR | |
| SCHEMBL2766519 | 0.70 | MLNR (0.82) | MLNR | |
| SCHEMBL2766211 | 0.70 | MLNR (1.00) | MLNR | |
| SCHEMBL14289422 | 0.69 | MLNR (0.53) | MLNRCHRM2CHRM1 | |
| SCHEMBL13404724 | 0.68 | MLNR (0.52) | MLNR | |
| SCHEMBL3922676 | 0.68 | MLNR (0.52) | MLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041093-A1 | PIPERAZINYL DERIVATIVES USEFUL IN THE TREATMENT OF GPR38 RECEPTOR MEDIATED DISEASES | Glaxo Group Limited (GB) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008000729-A1 | PIPERAZINYL DERIVATIVES USEFUL IN THE TREATMENT OF GPR38 RECEPTOR MEDIATED DISEASES | GLAXO GROUP LIMITED (GB) | 2008-01-03 | — | — | WO | disclosed |