Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 10/20 | 0.52 |
| ▸ | IGF1R | P08069 | 2/20 | 0.46 |
| ▸ | PLK4 | O00444 | 3/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | SUV39H1 | O43463 | 1/20 | 0.39 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4165938 | 1.00 | PAK4 (0.52) | PAK4IGF1RPLK4PTK2AURKA | |
| SCHEMBL4165932 | 1.00 | PAK4 (0.52) | PAK4IGF1RPLK4PTK2AURKA | |
| SCHEMBL4165549 | 0.96 | PAK4 (0.49) | PAK4IGF1RNTRK1 | |
| SCHEMBL4165541 | 0.96 | PAK4 (0.49) | PAK4IGF1RNTRK1 | |
| SCHEMBL4165865 | 0.96 | PAK4 (0.49) | PAK4IGF1RNTRK1 | |
| SCHEMBL4167037 | 0.95 | PAK4 (0.58) | PAK4IGF1RPLK4PTK2AURKA | |
| SCHEMBL4017086 | 0.93 | PAK4 (0.56) | PAK4IGF1RAURKARIPK1RET | |
| SCHEMBL4299093 | 0.88 | PAK4 (0.47) | PAK4IGF1RPLK4PTK2AURKA | |
| SCHEMBL4016099 | 0.88 | PAK4 (0.47) | PAK4IGF1RPLK4PTK2AURKA | |
| SCHEMBL4299975 | 0.86 | PAK4 (0.43) | PAK4PLK4PTK2AURKARIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090270418-A1 | PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, LLC | 2009-10-29 | — | — | US | claimed |
| WO-2009089042-A1 | PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, LLC (US) | 2009-07-16 | — | — | WO | claimed |
| US-20090270418-A1 | PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, LLC | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270418-A1 | PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH | MAP3K1, MAP3K15, MAP3K5 | PAK4 463/4885IGF1R 512/4885PLK4 182/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.