Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 15/20 | 0.66 |
| ▸ | CFTR | P13569 | 4/20 | 0.47 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL415244 | 0.80 | PDE10A (1.00) | PDE10A | |
| SCHEMBL415101 | 0.74 | C5AR1 (0.77) | C5AR1 | |
| SCHEMBL417038 | 0.72 | PDE10A (0.56) | PDE10A | |
| SCHEMBL20299095 | 0.72 | CFTR (0.64) | PDE10ACFTRC5AR1 | |
| SCHEMBL415782 | 0.72 | PDE10A (1.00) | PDE10A | |
| SCHEMBL415083 | 0.72 | PDE10A (0.70) | PDE10A | |
| SCHEMBL417086 | 0.71 | PDE10A (0.78) | PDE10A | |
| SCHEMBL417276 | 0.71 | PDE10A (0.75) | PDE10A | |
| SCHEMBL415771 | 0.70 | PDE10A (1.00) | PDE10A | |
| SCHEMBL415776 | 0.69 | PDE10A (1.00) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492392-B2 | Alkoxy tetrahydro-pyridopyrimidine PDE10 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2013-07-23 | — | — | US | disclosed |
| US-20120065211-A1 | ALKOXY TETRAHYDRO-PYRIDOPYRIMIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065211-A1 | ALKOXY TETRAHYDRO-PYRIDOPYRIMIDINE PDE10 INHIBITORS | PDE12, PDE4A, PDE5A | PDE10A 6/4885CFTR 2435/4885C5AR1 4387/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.