⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4172674 | 1.00 | — | — | |
| SCHEMBL4183741 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL12493059 | 0.98 | — | — | |
| SCHEMBL20880483 | 0.78 | — | — | |
| SCHEMBL24151274 | 0.74 | — | — | |
| SCHEMBL12133541 | 0.74 | — | — | |
| Hydrochloric Acid SCHEMBL1352431 | 0.72 | — | — | |
| SCHEMBL18124976 | 0.72 | — | — | |
| SCHEMBL14169716 | 0.72 | — | — | |
| SCHEMBL18124979 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12398136-B2 | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors | VENTUS THERAPEUTICS U.S., INC. (US) | 2025-08-26 | — | — | US | disclosed |
| US-20250236620-A1 | PYRIDO-[3,4-d]PYRIDAZINE AMINE DERIVATIVES USEFUL AS NLRP3 INHIBITORS | VENTUS THERAPEUTICS U S INC (US) | 2025-07-24 | — | — | US | disclosed |
| US-12331048-B2 | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors | VENTUS THERAPEUTICS U.S., INC. (US) | 2025-06-17 | — | — | US | disclosed |
| US-12312351-B2 | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors | VENTUS THERAPEUTICS U.S., INC. (US) | 2025-05-27 | — | — | US | disclosed |
| EP-4499638-A1 | PYRIDO-[3,4-D]PYRIDAZINE AMINE DERIVATIVES USEFUL AS NLRP3 DERIVATIVES | Ventus Therapeutics U.S., Inc. (US) | 2025-02-05 | — | — | EP | disclosed |
| WO-2025020886-A1 | AZAQUINAZOLINE RING DERIVATIVE AND USE THEREOF | 浙江星浩澎博医药有限公司 | 2025-01-30 | — | — | WO | disclosed |
| US-12195460-B2 | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors | VENTUS THERAPEUTICS U.S., INC. (US) | 2025-01-14 | — | — | US | disclosed |
| US-12168657-B2 | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives | VENTUS THERAPEUTICS U.S., INC. (US) | 2024-12-17 | — | — | US | disclosed |
| CN-119137121-A | Pyrido- [3,4-d ] pyridazinamine derivatives useful as NLRP3 derivatives | 万特斯治疗美国公司 | 2024-12-13 | — | — | CN | disclosed |
| US-20240409540-A1 | PYRIDO-[3,4-d]PYRIDAZINE AMINE DERIVATIVES USEFUL AS NLRP3 INHIBITORS | VENTUS THERAPEUTICS U S INC (US) | 2024-12-12 | — | — | US | disclosed |
| WO-2021063335-A1 | ERK1/2 PROTEIN KINASE INHIBITOR AND USE THEREOF | 南京药石科技股份有限公司 | 2021-04-08 | — | — | WO | disclosed |
| WO-2017153578-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2017-09-14 | — | — | WO | disclosed |
| EP-2857388-A1 | Azoles containing sulfone | Grünenthal GmbH (DE) | 2015-04-08 | — | — | EP | disclosed |
| EP-2857388-A1 | Azoles containing sulfone | Grünenthal GmbH (DE) | 2015-04-08 | — | — | EP | disclosed |
| US-20090227601-A1 | Bradykinin 1 Receptor Antagonists | AMGEN INC. (US) | 2009-09-10 | — | — | US | disclosed |
| EP-1963285-A1 | BRADYKININ 1 RECEPTOR ANTAGONISTS | Amgen Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| US-7332509-B2 | Heterocyclic amides, a process for their preparation, compositions comprising them and their use | MERIAL LIMITED (US) | 2008-02-19 | — | — | US | disclosed |
| US-7332509-B2 | Heterocyclic amides, a process for their preparation, compositions comprising them and their use | MERIAL LIMITED (US) | 2008-02-19 | — | — | US | disclosed |
| WO-2007067629-A1 | BRADYKININ 1 RECEPTOR ANTAGONISTS | AMGEN INC. (US) | 2007-06-14 | — | — | WO | disclosed |
| EP-1434485-B1 | NICOTINIC ACID-HETEROCYCLYL-AMIDES AND ANALOGOUS PYRIMIDINE DERIVATIVES FOR USE AS PESTICIDES | MERIAL LTD (US) | 2007-05-16 | — | — | EP | disclosed |