Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 10/20 | 0.52 |
| ▸ | AURKA | O14965 | 6/20 | 0.45 |
| ▸ | GRM5 | P41594 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4175441 | 1.00 | PAK4 (0.52) | PAK4AURKAGRM5 | |
| SCHEMBL4172938 | 1.00 | PAK4 (0.52) | PAK4AURKAGRM5 | |
| SCHEMBL4019626 | 0.95 | GRM5 (0.49) | PAK4AURKAGRM5 | |
| SCHEMBL4164410 | 0.95 | GRM5 (0.49) | PAK4AURKAGRM5 | |
| SCHEMBL4019640 | 0.95 | GRM5 (0.49) | PAK4AURKAGRM5 | |
| SCHEMBL4177709 | 0.95 | PAK4 (0.58) | PAK4AURKAGRM5 | |
| SCHEMBL4162081 | 0.91 | PAK4 (0.53) | PAK4AURKAGRM5 | |
| SCHEMBL4162099 | 0.91 | PAK4 (0.53) | PAK4AURKAGRM5 | |
| SCHEMBL4169907 | 0.91 | PAK4 (0.53) | PAK4AURKAGRM5 | |
| SCHEMBL4016833 | 0.89 | AURKA (0.46) | PAK4AURKAGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090270418-A1 | PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, LLC | 2009-10-29 | — | — | US | claimed |
| WO-2009089042-A1 | PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, LLC (US) | 2009-07-16 | — | — | WO | claimed |
| US-20090270418-A1 | PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, LLC | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270418-A1 | PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH | MAP3K1, MAP3K15, MAP3K5 | PAK4 463/4885AURKA 408/4885GRM5 1506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.