Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.66 |
| ▸ | BCR | P11274 | 2/20 | 0.66 |
| ▸ | CDK2 | P24941 | 17/20 | 0.62 |
| ▸ | CDK4 | P11802 | 12/20 | 0.62 |
| ▸ | AURKA | O14965 | 5/20 | 0.62 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.62 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.55 |
| ▸ | CDK9 | P50750 | 6/20 | 0.53 |
| ▸ | CDK1 | P06493 | 5/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.53 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.53 |
| ▸ | CDK7 | P50613 | 2/20 | 0.53 |
| ▸ | CCNH | P51946 | 1/20 | 0.53 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.52 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 2/20 | 0.51 |
| ▸ | JAK3 | P52333 | 2/20 | 0.51 |
| ▸ | CDC7 | O00311 | 1/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4162420 | 0.91 | CDK2 (0.64) | ABL1BCRCDK2CDK4AURKA | |
| SCHEMBL2074499 | 0.89 | CDK2 (0.57) | ABL1BCRCDK2CDK4AURKA | |
| SCHEMBL4156961 | 0.82 | CDK2 (0.80) | ABL1BCRCDK2CDK4AURKA | |
| SCHEMBL4166368 | 0.81 | CDK2 (0.74) | ABL1BCRCDK2CDK4AURKA | |
| SCHEMBL1806918 | 0.80 | CDK2 (0.74) | CDK2CDK4AURKAAURKBCCNE1 | |
| SCHEMBL4169340 | 0.80 | CDK2 (0.74) | ABL1CDK2CDK4AURKAAURKB | |
| SCHEMBL14100235 | 0.79 | ABL1 (0.67) | ABL1BCRCDK2CDK9CDK1 | |
| SCHEMBL4158463 | 0.79 | CDK2 (0.65) | ABL1BCRCDK2CDK4AURKA | |
| SCHEMBL4158569 | 0.77 | CDK2 (0.62) | ABL1BCRCDK2CDK4AURKA | |
| SCHEMBL2073867 | 0.77 | CDK2 (1.00) | ABL1BCRCDK2CDK4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137572-A1 | 2-substituted-4-heteroaryl-pyrimidines useful for the treatment of proliferative disorders | CYCLACEL LIMITED (GB) | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137572-A1 | 2-substituted-4-heteroaryl-pyrimidines useful for the treatment of proliferative disorders | CDK2, CDK4, CDK20 | ABL1 59/4885BCR 1047/4885CDK2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.